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      • Record: found
      • Abstract: found
      • Article: found

      Agonist-Induced Phosphatidylinositide Breakdown and Mitogenesis in Retinal Capillary Pericytes

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          Abstract

          We have examined the effects of a variety of vasoactive agents and growth factors on phosphatidylinositide turnover and DNA synthesis in cultured retinal capillary pericytes. A complex correlation between phosphatidylinositide turnover and DNA synthesis varied with different agonists. The resulting data indicate that phosphatidylinositide turnover is not the sole signaling pathway, and there must be multiple signaling pathways involved in pericyte mitogenesis.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1994
          Publication date (Print): 1994
          Publication date (Electronic): 11 December 2009
          Volume: 26
          Issue: 1
          Pages: 36-40
          Affiliations
          aDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, People’s Republic of China; bDepartment of Ophthalmology, Hahnemann University, Philadelphia, Pa., USA
          Article
          Publisher ID: 267372 Other ID: Ophthalmic Res 1994;26:36–40
          DOI: 10.1159/000267372
          PubMed ID: 7907779
          SO-VID: dde4b5fc-5f1d-4307-b961-0ac73ec1254e
          Copyright © © 1994 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 29 March 1993
          Date accepted : 29 July 1993
          Page count
          Pages: 5
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Mitogenesis,Growth factor,Inositol phosphate,Retinal capillary pericytes,Vasoactive agents
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Mitogenesis, Growth factor, Inositol phosphate, Retinal capillary pericytes, Vasoactive agents

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