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      Lipid-Lowering Trials: What Have They Taught Us about Morbidity and Mortality?

      Cardiology

      S. Karger AG

      Coronary artery disease, Clinical trials, Atherosclerosis, Risk factors, Lipoproteins

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          Abstract

          An abundance of clinical trial data indicates that lipid-regulating therapy reduces coronary artery disease morbidity and mortality. In patients with established coronary artery disease, lipid regulation has been shown to attenuate progression of atherosclerosis and extend survival. In primary prevention, a clear benefit of therapy on survival has not been demonstrated, leading some to question its value. However, the probability of false negatives for total mortality in primary-prevention trials is high, and the potential benefit of primary-prevention measures to public health is great. Additional investigations should further clarify the role of lipid-regulating therapy, particularly in important populations for whom fewer data are available, such as women and the elderly.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1996
          1996
          19 November 2008
          : 87
          : 6
          : 453-457
          Affiliations
          Department of Medicine, Baylor College of Medicine, Internal Medicine Service, The Methodist Hospital, Houston, Tex. USA
          Article
          177138 Cardiology 1996;87:453–457
          10.1159/000177138
          8904670
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Review

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