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      Síndrome de Wernicke-Korsakoff: revisão literária da sua base neuroanatómica Translated title: Wernicke-Korsakoff syndrome: a literary review on its neuroanatomical basis

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          Abstract

          O elevado consumo de álcool, não apenas por parte da população adulta mas também, e cada vez mais, por parte dos estratos mais jovens, apresenta-se como um problema de saúde pública preocupante. Uma das possíveis consequências do alcoolismo crónico é o desenvolvimento do síndrome de Wernicke-Korsakoff. O síndrome de Wernicke-Korsakoff é um grupo de sinais e sintomas neuropsiquiátricos induzido por uma deficiência nutricional de vitamina B1 (tiamina). Esta doença, sem um tratamento adequado, pode progredir para um estado de estupor, coma e até morte. Os autores esclarecem a sua fisiopatologia e manifestações e, no processo, foi realizada uma revisão literária.

          Translated abstract

          High consumption of alcohol, not only by the adult population but also, and ever increasing, by younger strata, presents itself as a worrisome public health issue. One of the possible consequences of chronic alcohol consumption is the development of the Wernicke-Korsakoff syndrome. it is a group of neuropsychiatric signs and symptoms induced by a nutritional deficiency of vitamin B1 (thiamine). This disease, without proper treatment, can progress to a state of stupor, coma and even death. The authors shed a light on its pathophysiology and manifestations and, in the process, a literary review was undertaken.

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          Most cited references 43

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          Tuberculosis: a benign impostor.

          The purpose of this article is to illustrate the overlapping radiologic patterns in proven tuberculosis cases in patients initially referred to our cancer center for presumed malignancy. Tuberculosis can simulate malignancy both clinically and radiologically, especially in its extrapulmonary form.
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            Clinical features of leuko-araiosis.

            To study the clinical features of leuko-araiosis. Age matched groups of patients with a CT finding of pure leukoaraiosis (n = 26) and a control group with a normal CT finding (n = 26) were formed (mean ages 78.6 (SD 3.3) v 76.5 (SD 4.6) years; NS). Dementia, vascular dementia, central brain atrophy on CT, disability in activities of daily living and instrumental activities of daily living, urinary incontinence, gait disorder (assistance needed), personality change, and night time confusion were found to be more commonly present in leuko-araiosis positive patients than in controls, whereas focal neurological symptoms and signs were not associated with leuko-araiosis. The occurrences of heart failure and systolic hypotension-but not hypertension-were higher in the leuko-araiosis positive group than in the controls. Leuko-araiosis was also found to be related to a less sudden onset of symptoms and a lower Hachinski score than true brain infarction(s). Leuko-araiosis on CT in these elderly patients seems to be a vascular disorder aetiologically different from brain infarction, with clinical manifestations of subtle onset and general disabling nature and no prominent focal neurological signs or symptoms.
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              THE ROYAL COLLEGE OF PHYSICIANS REPORT ON ALCOHOL: GUIDELINES FOR MANAGING WERNICKE'S ENCEPHALOPATHY IN THE ACCIDENT AND EMERGENCY DEPARTMENT

               A D Thomson (2002)
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Journal
                am
                Arquivos de Medicina
                Arq Med
                ArquiMed - Edições Científicas AEFMUP (Porto )
                2183-2447
                June 2013
                : 27
                : 3
                : 121-127
                Affiliations
                [1 ] Universidade do Porto Portugal
                Article
                S0871-34132013000300004
                Product
                Product Information: website
                Categories
                MEDICINE, GENERAL & INTERNAL

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