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      Pharmacokinetics of Ethynyl Estradiolsulfonate in Minipigs

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          Abstract

          The pharmacokinetics of ethynyl estradiolsulfonate labelled with <sup>3</sup>H in the steroid nucleus and with <sup>14</sup>C in the isopropylsulfonic acid side chain was investigated in male minipigs. The plasma level after intravenous administration was interpreted according to a three-compartment model. After oral administration the first two phases were overlapped by the absoφtion period. The renal and fecal excretion of the two labellings were investigated. In urine the majority of the <sup>3</sup>H-labelled steroid was excreted in the unconjugated and in the glucuronide fractions. More than 70% of <sup>14</sup>C in urine was unextractable.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1984
          1984
          26 November 2008
          : 19
          : 1
          : 57-64
          Affiliations
          Department of Pharmacology, Research Division of VEB Jenapharm, Jena, GDR
          Article
          179840 Horm Res 1984;19:57–64
          10.1159/000179840
          6693060
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 8
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