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      A Retrograde Transaortic/Transmitral Approach for Radiofrequency Ablation of Adenosine-Sensitive Atrial Tachycardia Arising Near the Apex of Koch’s Triangle: A Case Study Approach and Review of the Literature

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          Abstract

          Atrial tachycardias (ATs) are relatively uncommon and their mechanisms include reentry or may be focal. The characteristics and radiofrequency (RF) ablation of adenosine-sensitive AT arising near the apex of Koch’s triangle have been reported. We report a case of successful RF ablation of this tachycardia by using a retrograde transaortic/transmitral approach. An electrophysiological study performed during sinus rhythm showed continuous anterograde atrioventricular nodal and no ventriculoatrial conduction. The tachycardia could be induced and terminated by atrial extrastimulation and rapid atrial pacing. Although inverse resetting response pattern was observed, tachycardia termination by intravenous low-dose adenosine was rather suggestive of triggered activity as the mechanism. The earliest atrial activation was recorded in the His-bundle region. After ineffective right-sided attempts and failure to find earlier atrial activity during mapping the noncoronary sinus of Valsalva, this tachycardia was successfully ablated from the left atrial septum by using a retrograde transaortic/transmitral approach. This report demonstrates the feasibility of a novel retrograde left atrial approach for RF ablation of adenosine-sensitive AT originating from the apex of Koch’s triangle.

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          Most cited references41

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          Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation.

          Mechanisms and electropharmacological characteristics in adult patients with atrial tachycardia (AT) are not well described. We proposed that a combination of electropharmacological characteristics, recording of monophasic action potential, and effects of radiofrequency ablation could further determine the mechanisms and achieve a new classification in adults with various types of AT because they were important in regard to the correlation between mechanisms and pathophysiology, clinical syndrome, and responses to specific pharmacological or nonpharmacological therapies. Thirty-six patients (11 female, 25 male; mean age, 57 +/- 13 years) with AT were referred for electropharmacological studies and radiofrequency ablation. Resetting response pattern, entrainment phenomenon, recording of monophasic action potential, serial drug test, response to Valsalva maneuver, endocardial mapping technique, and radiofrequency ablation were performed. Seven patients had automatic AT provocable with isoproterenol; neither initiation nor termination was related to programmed electrical stimulation. The other 29 patients had AT initiated or terminated by electrical stimulation and mechanisms related to triggered activity or reentry; nine of them needed isoproterenol to facilitate initiation of AT, associated with delayed afterdepolarization in monophasic action potential. All responded to adenosine (15 to 60 micrograms/kg) and Valsalva maneuver. Dipyridamole terminated AT and decreased the slope of afterdepolarization. Afterdepolarization was not found in the patients with automatic or reentrant AT. In 40 of 41 (98%), AT was ablated successfully, with late recurrence in 2 of 40 (5%) (follow-up, 18 +/- 4 months). This study demonstrates the diverse mechanisms and electropharmacological characteristics of AT in adults. Furthermore, radiofrequency ablation of various types of AT could achieve high success and low recurrence rates.
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            Focal atrial tachycardia originating from the non-coronary aortic sinus: electrophysiological characteristics and catheter ablation.

            We sought to investigate electrophysiological characteristics and catheter ablation in patients with focal atrial tachycardia (AT) originating from the non-coronary aortic sinus (AS). In patients with failed ablation of focal AT near the His bundle (HB) region, an origin from the non-coronary AS should be considered because of the close anatomical relationship. This study included 9 patients with focal AT, in 6 of whom attempted radiofrequency (RF) ablation had previously failed. Activation mapping was performed during tachycardia to identify an earliest activation in the atria and the AS. The aortic root angiography was performed to identify the origin in the AS before RF ablation. Focal AT was reproducibly induced by atrial pacing. Mapping in atria demonstrated that the earliest atrial activation was located at the HB region, whereas mapping in the non-coronary AS demonstrated that an earliest atrial activation preceded the atrial activation at the HB by 12.2 +/- 6.9 ms and was anatomically located superoposterior to the HB in all 9 patients. Also, His potentials were not found at the successful site in the non-coronary AS in all 9 patients. The focal AT was terminated in <8 s in all 9 patients. Junctional beats and PR prolongation did not occur during RF application in all 9 patients. No complications occurred in any of the nine patients. All 9 patients were free of arrhythmias without antiarrhythmic drugs during a follow-up of 9 +/- 3 months. In patients with focal AT near the HB region, mapping in the non-coronary AS can improve clinical outcome.
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              Initiating reentry: the role of nonuniform anisotropy in small circuits.

              Until recently only two types of media have been considered to provide the nonuniformities necessary to initiate cardiac reentry: (1) continuous isotropic media with intrinsic repolarization inhomogeneities; and (2) continuous isotropic media free of inhomogeneities in which repolarization nonuniformities are introduced transiently. The purpose of this article is to establish cellular coupling as a basis for arrhythmias by placing a new type of inhomogeneity, nonuniform anisotropy due to sparse side-to-side coupling between cells, in an overall perspective with the other nonuniformities that lead to reentry. Review of experimental and theoretical models of reentry leads to the following picture: with slowed conduction, reentrant circuits diminish in size and the nonuniformities necessary for reentry are provided by nonuniform anisotropy. Repolarization nonuniformities create functionally different pathways for reentrant circuits of relatively large size (> 30-50 mm2). Nonuniform anisotropic cellular coupling, which is associated with underlying microfibrosis, makes it possible for reentry to occur in small areas (< 10-15 mm2). A general property found in nonuniform anisotropic bundles is the presence of functionally different pathways in the absence of intrinsic repolarization inhomogeneities--one of fast longitudinal conduction with a longer refractory period, and another of "very slow" transverse conduction with a shorter refractory period. Since it is not known if nonuniform anisotropy exists in the AV node, the best known structure with small reentrant circuits, we performed microscopic extracellular measurements in the AV node of the rabbit. The transitional zone of the AV node was found to have markedly nonuniform anisotropic conduction properties. The analysis provides the view that functionally different pathways of small reentrant circuits, including those of the AV node, need to be reevaluated in terms of the role of nonuniform anisotropic cellular coupling.
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                Author and article information

                Journal
                Cardiol Res
                Cardiol Res
                Elmer Press
                Cardiology Research
                Elmer Press
                1923-2829
                1923-2837
                February 2019
                24 February 2019
                : 10
                : 1
                : 48-53
                Affiliations
                [a ]Department of Cardiology and Angiology, Augusta-Kranken-Anstalt, Bergstrasse 26, 44791 Bochum, Germany
                Author notes
                [b ]Corresponding Author: Jan Hluchy, Department of Cardiology and Angiology, Bergstrasse 26, 44791 Bochum, Germany. Email: hluchy@ 123456degedi.de
                Article
                10.14740/cr806
                6396805
                de3db594-3524-429c-a14a-139376379d1b
                Copyright 2019, Hluchy et al.

                This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 12 November 2018
                : 26 November 2018
                Categories
                Case Report

                atrial tachycardia,av nodal reentry,radiofrequency ablation

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