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      Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects

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          Abstract

          The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicity and anti-inflammatory effects of triptolide (TP). A water extract was prepared from A. lancea rhizomes and co-administered with TP in C57BL/6 mice. The toxicity was assayed by determining serum biochemical parameters and visceral indexes and by liver histopathological analysis. The hepatic CYP3A expression levels were detected using Western blotting and RT-PCR methods. The data showed that the water extract of A. lancea rhizomes reduced triptolide-induced toxicity, probably by inducing the hepatic expression of CYP3A. The anti-inflammatory effects of TP were evaluated in mice using a xylene-induced ear edema test. By comparing ear edema inhibition rates, we found that the water extract could also increase the anti-inflammatory effects of TP. In conclusion, our results suggested that the water extract of A. lancea rhizomes, used in combination with TP, has a potential in reducing TP-induced toxicity and enhancing its anti-inflammatory effects.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 December 2017
          : 15
          : 12
          : 905-911
          Affiliations
          1School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
          2Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
          Author notes
          *Corresponding author: WEI Yuan, Tel/Fax: +86-0511-85038750; E-mail: ywei@ 123456ujs.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30006-2
          10.1016/S1875-5364(18)30006-2
          29329647
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81102522
          Award ID: 81373480
          Funded by: Natural Science Foundation of Jiangsu Province
          Award ID: BK2011473
          This work was supported by the National Natural Science Foundation of China (Nos. 81102522 and 81373480), the Natural Science Foundation of Jiangsu Province (No. BK2011473), and the Excellent Youth Foundation of Jiangsu University.

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