0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Adrenergic Drugs and Intraocular Pressure: the Hypertensive Effect of Epinephrine

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Topical application of some catecholamines to the eye can cause a transient ocular hypertensive response; a drug effect that has had various explanations. We tested the hypothesis that this effect is mediated by α-adrenoceptor stimulation and consequent contraction of extraocular muscles. We found that surgical section of three major extraocular muscles completely eliminated the initial ocular hypertensive effect and revealed an ocular hypotensive effect of topical epinephrine in rabbits. This agent is not known to cause contralateral pressure effects in normal eyes, however, in the surgically altered subjects the intact fellow eyes developed a late reduction in intraocular pressure, the significance of which remains obscure. Pupil dilatation was slightly greater in epinephrine-treated, surgically altered eyes than in normal eyes.

          Related collections

          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1980
          1980
          03 December 2009
          : 12
          : 4
          : 221-229
          Affiliations
          Department of Pharmacology and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, Tex.
          Article
          265081 Ophthalmic Res 1980;12:221–229
          10.1159/000265081
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Original Paper

          Comments

          Comment on this article