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Upper respiratory infections in children: response to endonasal administration of IGA
March 1997
March 1997
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Abstract
Children, 36, predisposed to frequent upper respiratory infections were treated with
endonasal administration of an IgA enriched preparation or placebo in a randomized
double blind trial. We found a reduction in the number of infectious episodes and
in the number of enlarged regional lymph nodes. Also, an increase of IgA levels in
saliva in the treated group was observed, probably not only due to the effect of IgA
supplementation, but also to an immunoregulatory effect on the mucosa caused by the
preparation administered. We found this therapy very useful in the prophylaxis of
upper respiratory infections, being the nasal administration very convenient to be
used in children.