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      Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli

      , , ,
      Nanomedicine: Nanotechnology, Biology and Medicine
      Elsevier BV

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          Abstract

          Silver nanoparticles (Ag-NPs) have been known to have inhibitory and bactericidal effects. Resistance to antimicrobial agents by pathogenic bacteria has emerged in recent years and is a major health problem. The combination effects of Ag-NPs with the antibacterial activity of antibiotics have not been studied. Here, we report on the synthesis of metallic nanoparticles of silver using a reduction of aqueous Ag(+) ion with the culture supernatants of Klebsiella pneumoniae. Also in this article these nanoparticles are evaluated for their part in increasing the antimicrobial activities of various antibiotics against Staphylococcus aureus and Escherichia coli. The antibacterial activities of penicillin G, amoxicillin, erythromycin, clindamycin, and vancomycin were increased in the presence of Ag-NPs against both test strains. The highest enhancing effects were observed for vancomycin, amoxicillin, and penicillin G against S. aureus.

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          Most cited references13

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          Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum

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            The study of antimicrobial activity and preservative effects of nanosilver ingredient

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              Bacterial resistance to antibiotics: enzymatic degradation and modification.

              D. Wright (2005)
              Antibiotic resistance can occur via three general mechanisms: prevention of interaction of the drug with target, efflux of the antibiotic from the cell, and direct destruction or modification of the compound. This review discusses the latter mechanisms focusing on the chemical strategy of antibiotic inactivation; these include hydrolysis, group transfer, and redox mechanisms. While hydrolysis is especially important clinically, particularly as applied to beta-lactam antibiotics, the group transfer approaches are the most diverse and include the modification by acyltransfer, phosphorylation, glycosylation, nucleotidylation, ribosylation, and thiol transfer. A unique feature of enzymes that physically modify antibiotics is that these mechanisms alone actively reduce the concentration of drugs in the local environment; therefore, they present a unique challenge to researchers and clinicians considering new approaches to anti-infective therapy. This review will present the current status of knowledge of these aspects of antibiotic resistance and discuss how a thorough understanding of resistance enzyme molecular mechanism, three-dimensional structure, and evolution can be leveraged in combating resistance.
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                Author and article information

                Journal
                Nanomedicine: Nanotechnology, Biology and Medicine
                Nanomedicine: Nanotechnology, Biology and Medicine
                Elsevier BV
                15499634
                June 2007
                June 2007
                : 3
                : 2
                : 168-171
                Article
                10.1016/j.nano.2007.02.001
                17468052
                de517ad3-f650-4afe-9393-71b76fcdb9ad
                © 2007

                https://www.elsevier.com/tdm/userlicense/1.0/

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