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      Medulloblastoma: developmental mechanisms out of control.

      Trends in Molecular Medicine
      Animals, Cell Cycle, Cerebellar Neoplasms, embryology, metabolism, Cerebellum, growth & development, Hedgehog Proteins, Humans, Intercellular Signaling Peptides and Proteins, genetics, Medulloblastoma, Membrane Proteins, Mice, Mice, Mutant Strains, Mice, Transgenic, Nuclear Proteins, Polycomb Repressive Complex 1, Proto-Oncogene Proteins, Receptors, Notch, Repressor Proteins, Signal Transduction, Trans-Activators, Wnt Proteins

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          Abstract

          Medulloblastoma, which is a highly aggressive central nervous system neoplasm, represents an intriguing example of how deregulated developmental mechanisms can lead to tumour development. Recent advances in the understanding of the role of Sonic Hedgehog, Wnt and Notch signalling pathways in the development of the cerebellum have shed new light on medulloblastoma pathogenesis.

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