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      Clinical recommendations for defining platinum unsuitable head and neck cancer patient populations on chemoradiotherapy: A literature review.

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          Abstract

          Toxicities resulting from platinum based chemotherapy in head and neck cancer is a cause for much concern. There is a lack of clinical criteria for defining these patient populations, which has posed serious problems associated with increased morbidity and consequently an adverse effect on patients' quality of life. In addition, there is a lack of consensus on clinical criteria for defining such patient populations, who may be unsuitable for concurrent chemoradiotherapy. A group of experts in the field of head and neck cancer from the Asia Pacific Region convened in August 2014 in Korea to discuss the development of a set of clinical criteria in order to fill the knowledge gap and provide a reference tool for head and neck oncologists. This paper reports the final output from this meeting and the accompanying literature review, with the aim of aiding clinical decision making with the help of some clinical criteria to identify platinum unsuitable patient populations in head and neck cancer management. Some alternative treatment options are also discussed in this paper.

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          Author and article information

          Journal
          Oral Oncol.
          Oral oncology
          1879-0593
          1368-8375
          Feb 2016
          : 53
          Affiliations
          [1 ] Samsung Medical Center, Seoul, Republic of Korea.
          [2 ] Tata Memorial Hospital, Mumbai, India.
          [3 ] University Hospital Antwerp, Edegem, Belgium.
          [4 ] National Taiwan University Hospital, Taipei, Taiwan.
          [5 ] Chiang Mai Hospital, Chiang Mai University, Chiang Mai, Thailand.
          [6 ] Ho Chi Minh City Oncology Hospital, Ho Chi Minh City, Viet Nam.
          [7 ] Royal North Shore Hospital, Sydney, Australia.
          [8 ] King Chulalongkorn University Hospital, Bangkok, Thailand.
          [9 ] Sun Yat-Sen University Cancer Center, Guangzhou, China.
          [10 ] Pamela Youde Nethersole Eastern Hospital, Hong Kong.
          [11 ] Keimyung University Dongsan Medical Center, Daegu, Republic of Korea.
          [12 ] Chinese University of Hong Kong, Hong Kong. Electronic address: anthonytcchan@cuhk.edu.hk.
          Article
          S1368-8375(15)00397-8
          10.1016/j.oraloncology.2015.11.019
          26712252
          de73e7da-6719-4d03-ad5b-449eb3f4c05e
          Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
          History

          Chemoradiotherapy,Cisplatin,Criteria,Expert opinion,Head and neck cancer,Patients,Toxicity,Unsuitability

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