Insulin Resistance and Polycystic Ovarian Syndrome

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Abstract

Insulin resistance (IR) and polycystic ovarian syndrome (PCOS) appear as linked phenomena, although this is not easy to obviate in common forms of PCOS while it is evident in the rare cases of extreme IR and hyperinsulinism (HI). Experimental data indicate that insulin could interfere with the local insulin-like growth factor systems in ovaries, and presumably in adrenals and in the hypothalamic pituitary system. The female puberty system offers a physiological model to explain the gonadotropic action of insulin. In patients with IR, HI could induce a state of hyperpuberty, leading to the constitution of PCOS during adolescence.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5784-9

ISBN: 978-3-318-01952-0

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 03 December 2008

Volume: 38

Issue: 1-2

Pages: 41-45

Affiliations

Service d’Endocrinologie et de Diabétologie, USN A-CHRU de Lille, France

Article

Publisher ID: 182482 Other ID: Horm Res 1992;38:41–45

DOI: 10.1159/000182482

PubMed ID: 1306514

SO-VID: de88b777-b034-4096-8d3d-f0bbe406faac

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Insulin Resistance and Polycystic Ovarian Syndrome

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Karger: Endocrinology

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