Nutritional Status, Time of Day and Pinealectomy: Factors Influencing the Sensitivity of the Neuroendocrine-Reproductive Axis of the Rat to Melatonin

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Abstract

Afternoon but not morning injections of melatonin (Mel) resulted in significant 68, 50 and 20% reductions in seminal vesicle, ventral prostate and testicular weights, respectively, as compared with underfed controls. As in the animals injected in the morning, reproductive organ weights in underfed-pinealectomized rats were unaffected by afternoon injections of Mel. Both pituitary and serum prolactin levels were significantly depressed in underfed rats receiving Mel in the afternoon; however, Mel was ineffective when given either in the morning or to pinealectomized rats. These data indicate that there is a diurnal rhythm of sensitivity to Mel in undernourished rats which is abolished by pinealectomy.

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Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 25 November 2008

Volume: 14

Issue: 2

Pages: 104-113

Affiliations

Department of Anatomy, University of Arizona College of Medicine, Tucson, Ariz., USA

Article

Publisher ID: 179367 Other ID: Horm Res 1981;14:104–113

DOI: 10.1159/000179367

PubMed ID: 7275001

SO-VID: de94f37f-ec18-4065-bbb8-49a45f5b01e7

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 04 August 1980

Date accepted : 23 January 1981

Page count

Pages: 10

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