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      Nutritional Status, Time of Day and Pinealectomy: Factors Influencing the Sensitivity of the Neuroendocrine-Reproductive Axis of the Rat to Melatonin

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          Afternoon but not morning injections of melatonin (Mel) resulted in significant 68, 50 and 20% reductions in seminal vesicle, ventral prostate and testicular weights, respectively, as compared with underfed controls. As in the animals injected in the morning, reproductive organ weights in underfed-pinealectomized rats were unaffected by afternoon injections of Mel. Both pituitary and serum prolactin levels were significantly depressed in underfed rats receiving Mel in the afternoon; however, Mel was ineffective when given either in the morning or to pinealectomized rats. These data indicate that there is a diurnal rhythm of sensitivity to Mel in undernourished rats which is abolished by pinealectomy.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 14
          : 2
          : 104-113
          Department of Anatomy, University of Arizona College of Medicine, Tucson, Ariz., USA
          179367 Horm Res 1981;14:104–113
          © 1981 S. Karger AG, Basel

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          Pages: 10
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