Blog
About

113
views
0
recommends
+1 Recommend
0 collections
    19
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The hypothesis that quiescent CD4+ T lymphocytes carrying proviral DNA provide a reservoir for human immunodeficiency virus-type 1 (HIV-1) in patients on highly active antiretroviral therapy (HAART) was examined. In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4+ T lymphocytes. The frequency of resting CD4+ T cells harboring latent HIV-1 was low, 0.2 to 16.4 per 10(6) cells, and, in cross-sectional analysis, did not decrease with increasing time on therapy. The recovered viruses generally did not show mutations associated with resistance to the relevant antiretroviral drugs. This reservoir of nonevolving latent virus in resting CD4+ T cells should be considered in deciding whether to terminate treatment in patients who respond to HAART.

          Related collections

          Author and article information

          Affiliations
          [1 ] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
          Journal
          Science
          Science (New York, N.Y.)
          0036-8075
          0036-8075
          Nov 14 1997
          : 278
          : 5341
          9360927

          Comments

          Comment on this article