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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.

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      Abstract

      The hypothesis that quiescent CD4+ T lymphocytes carrying proviral DNA provide a reservoir for human immunodeficiency virus-type 1 (HIV-1) in patients on highly active antiretroviral therapy (HAART) was examined. In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4+ T lymphocytes. The frequency of resting CD4+ T cells harboring latent HIV-1 was low, 0.2 to 16.4 per 10(6) cells, and, in cross-sectional analysis, did not decrease with increasing time on therapy. The recovered viruses generally did not show mutations associated with resistance to the relevant antiretroviral drugs. This reservoir of nonevolving latent virus in resting CD4+ T cells should be considered in deciding whether to terminate treatment in patients who respond to HAART.

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      Affiliations
      [1 ] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
      Journal
      Science
      Science (New York, N.Y.)
      0036-8075
      0036-8075
      Nov 14 1997
      : 278
      : 5341
      9360927

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