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      Absence of Tobramycin Pharmacokinetic and Creatinine Clearance Variation During the Menstrual Cycle: Implied Absence of Variation in Glomerular Filtration Rate

      , ,
      The Journal of Clinical Pharmacology
      Wiley

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          A pharmacokinetic analysis program (multi) for microcomputer.

          A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses of ampicillin and oxacillin in man.
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            Renal functional reserve in humans

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              Use of Serum Creatinine Concentrations to Determine Renal Function1

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                Author and article information

                Journal
                The Journal of Clinical Pharmacology
                Wiley
                00912700
                August 1989
                August 1989
                March 08 2013
                : 29
                : 8
                : 757-763
                Article
                10.1002/j.1552-4604.1989.tb03413.x
                deb54cd0-47c6-4b78-b13d-6bff08f5ce37
                © 2013

                http://doi.wiley.com/10.1002/tdm_license_1.1

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