Enhanced proliferation of rabbit chondrocytes by using a well circulated nanoshock system

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Abstract

The gold nanorods (GNRs) embedded alginate-chitosan (scaffold), which was designed and fabricated to produce efficient handling of the cell proliferations. Scaffold embedded GNR (SGNR) and NIR (near infrared) irradiations are developing into an interesting medical prognosis tool for rabbit chondrocyte (RC) proliferation. SGNR contained a pattern of uniform pores. Biocompatibility and cellular proliferation achieved by disclosures to NIR irradiations, providing high cell survival. SGNR and NIR irradiations could produce mechanical and biochemical cues for regulating RCs proliferations. To determine the thermal stress, it exposed RCs to 39–42 °C for 0–240 min at the start point of the cell culture cycle. It produced photothermal stress in cellular surrounding (cells located adjacent to and within scaffold) and it deals with the proliferation behavior of RC. All the processes were modeled with experimental criteria and time evolution process. Our system could help the cell proliferation by generating heat for cells. Hence, the present strategy could be implemented for supporting cell therapeutics after transplantation. This implementation would open new design techniques for integrating the interfaces between NIR irradiated and non-irradiated tissues.

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Author and article information

Contributors

Kwangmeyung Kim: kim@kist.re.kr

Dong Kee Yi: vitalis@mju.ac.kr

Journal

Journal ID (nlm-ta): Sci Rep

Journal ID (iso-abbrev): Sci Rep

Title: Scientific Reports

Publisher: Nature Publishing Group UK (London )

ISSN (Electronic): 2045-2322

Publication date (Electronic): 29 September 2021

Publication date PMC-release: 29 September 2021

Publication date Collection: 2021

Volume: 11

Electronic Location Identifier: 19388

Affiliations

[1 ]GRID grid.410898.c, ISNI 0000 0001 2339 0388, Department of Chemistry, , Myongji University, ; Yongin, 03674 South Korea

[2 ]GRID grid.35541.36, ISNI 0000000121053345, Center for Theragnosis, Biomedical Research Institute, , Korea Institute of Science and Technology (KIST), ; Seoul, 02792 South Korea

[3 ]GRID grid.256155.0, ISNI 0000 0004 0647 2973, Department of Bionanotechnology, Gachon Medical Research Institute, , Gachon University, ; Seongnam, 13120 South Korea

[4 ]GRID grid.222754.4, ISNI 0000 0001 0840 2678, Korea University (KU)-KIST Graduate School of Converging Science and Technology, ; Seoul, 02841 South Korea

[5 ]GRID grid.35541.36, ISNI 0000000121053345, Optoelectronic Materials and Devices Research Center, , Korea Institute of Science and Technology (KIST), ; Seoul, 02792 South Korea

Article

Publisher ID: 98929

DOI: 10.1038/s41598-021-98929-2

PMC ID: 8481538

PubMed ID: 34588578

SO-VID: ded14485-30b7-4abb-8633-ed3d3e7a99d4

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 11 January 2021

Date accepted : 14 September 2021

Funding

Funded by: Korean National Research Foundation

Award ID: 2021R1F1A1048388

Award Recipient : Dong Kee Yi

Custom metadata

ScienceOpen disciplines: Uncategorized

Keywords: biological techniques,materials science,nanoscience and technology

Data availability:

ScienceOpen disciplines: Uncategorized

Keywords: biological techniques, materials science, nanoscience and technology

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