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      Effect of Au-dextran NPs as anti-tumor agent against EAC and solid tumor in mice by biochemical evaluations and histopathological investigations.

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          Abstract

          Dextran-capped gold nanoparticles (Au-dextran NPs) were prepared exploiting the natural polysaccharide polymer as both reducing and stabilizing agent in the synthesis process, aiming at studying their antitumor effect on solid carcinoma and EAC-bearing mice. To this end, Au-dextran NPs were designed via simple eco-friendly chemical reaction and they were characterized revealing the monodispersed particles with narrow distributed size of around 49nm with high negative charge. In vivo experiments were performed on mice. Biochemical analysis of liver and kidney functions and oxidation stress ratio in addition to histopathological investigations of such tumor tissues were done demonstrating the potentiality of Au-dextran NPs as antitumor agent. The obtained results revealed that EAC and solid tumors caused significant increase in liver and kidney functions, liver oxidant parameters, alpha feto protein levels and diminished liver antioxidant accompanied by positive expression of tumor protein p53 of liver while the treatment with Au-dextran NPs for both types caused improvement in liver and kidney functions, increased liver antioxidant, increased the expression level of B-cell lymphoma 2 gene and subsequently suppressed the apoptotic pathway. As a result, the obtained data provides significant antitumor effects of the Au-dextran NPs in both Ehrlich ascites and solid tumor in mice models.

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          Author and article information

          Journal
          Biomed. Pharmacother.
          Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
          Elsevier BV
          1950-6007
          0753-3322
          May 15 2017
          : 91
          Affiliations
          [1 ] Medical Biochemistry Department, National Research Center, 33 El Behouth St., 12622 Dokki, Giza, Egypt.
          [2 ] Pre-Treatment and Finishing of Cellulosic Fabric Department, Textile Research Division, National Research Centre, Dokki, Giza, Egypt. Electronic address: mehrez_chem@yahoo.com.
          [3 ] Pre-Treatment and Finishing of Cellulosic Fabric Department, Textile Research Division, National Research Centre, Dokki, Giza, Egypt. Electronic address: mattianrc@hotmail.fr.
          [4 ] Cell Biology Department, National Research Center, 33 El-Behouth St.,12622 Dokki, Giza, Egypt.
          [5 ] Pathology Department, National Research Centre, Dokki, Giza, Egypt.
          Article
          S0753-3322(17)31286-6
          10.1016/j.biopha.2017.05.043
          28525943
          ded294f9-6db5-48e8-91f7-4e8da03ea75b
          History

          B-cell lymphoma 2,Caspase 3,Dextran,Ehrlich ascites carcinoma,Gold nanoparticles,Solid tumor

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