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      Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma.

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          Abstract

          Omalizumab, a humanized anti-IgE monoclonal antibody, has demonstrated efficacy in patients with severe allergic asthma. However, treatment responses vary widely among individuals. Despite a lack of data, free serum IgE levels following omalizumab treatment have been proposed as a marker of treatment responsiveness.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Allergy
          Title: Allergy
          Publisher: Wiley-Blackwell
          ISSN (Electronic): 1398-9995
          ISSN (Print): 0105-4538
          Publication date (Electronic): Oct 2016
          Volume: 71
          Issue: 10
          Affiliations
          [1 ] Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
          [2 ] Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. hmatsumo@kuhp.kyoto-u.ac.jp.
          [3 ] Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
          [4 ] Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
          [5 ] Respiratory Center, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
          [6 ] Shino-Test Corporation, Kanagawa, Japan.
          [7 ] Department of Laboratory Medicine, Saga Medical School, Saga, Japan.
          [8 ] Division of Respiratory Medicine, Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences, Aichi, Japan.
          Article
          DOI: 10.1111/all.12922
          PubMed ID: 27113353
          SO-VID: ded35e1d-93c5-4612-8559-8a9dde0d3283
          History

          Keywords: treatment responsiveness,omalizumab,periostin,serum free IgE,asthma
          Data availability:
          Keywords: treatment responsiveness, omalizumab, periostin, serum free IgE, asthma

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