miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis.

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Abstract

MicroRNAs, such as miR-34, have been reported to influence age-related diseases. In this study, we explored the role of the miR-34a/Bcl-2 signaling pathway in age-related hearing loss (AHL). Using an AHL mouse model (C57BL/6), we found that the expression of miR-34a in the cochlea increased with age, whereas expression of Bcl-2 decreased. Increasing the amount of a miR-34a mimetic in a mouse auditory cell line (HEI-OC1) inhibited Bcl-2, leading to enhanced apoptosis; in contrast, miR-34a inhibition produced the opposite effect. Our results support a link between age-related cochlear hair cell apoptosis and miR-34a/Bcl-2 signaling. The latter may thus serve as a potential target for AHL therapy.

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Author and article information

Journal

Journal ID (iso-abbrev): Neurosci. Lett.

Title: Neuroscience letters

Publisher: Elsevier BV

ISSN (Electronic): 1872-7972

ISSN (Print): 0304-3940

Publication date (Electronic): Nov 20 2017

Volume: 661

Affiliations

[1 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: hqh_sysu@126.com.

[2 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: yiqingzheng@hotmail.com.

[3 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: yongkang_ou@yahoo.com.

[4 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: drxionghao@gmail.com.

[5 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: yanghaidi1978@163.com.

[6 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: zhangzz0369@126.com.

[7 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: chensuijun@hotmail.com.

[8 ] Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: 381297751@qq.com.

Article

Publisher Item ID: S0304-3940(17)30616-X

DOI: 10.1016/j.neulet.2017.07.044

PubMed ID: 28756190

SO-VID: dedd5a54-dbc0-4b30-8be7-ea17220588b6

History

Keywords: Presbycusis,miR-34a,Cochlea,Bcl-2,Apoptosis

Data availability:

Keywords: Presbycusis, miR-34a, Cochlea, Bcl-2, Apoptosis

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