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      Gut microbiota and chronic kidney disease: implications for novel mechanistic insights and therapeutic strategies.

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          Abstract

          The complicated communities of microbiota colonizing the human gastrointestinal tract exert a strong function in health maintenance and disease prevention. Indeed, accumulating evidence has indicated that the intestinal microbiota plays a key role in the pathogenesis and development of chronic kidney disease (CKD). Modulation of the gut microbiome composition in CKD may contribute to the accumulation of gut-derived uremic toxins, high circulating level of lipopolysaccharides and immune deregulation, all of which play a critical role in the pathogenesis of CKD and CKD-associated complications. In this review, we discuss the recent findings on the potential impact of gut microbiota in CKD and the underlying mechanisms by which microbiota can influence kidney diseases and vice versa. Additionally, the potential efficacy of pre-, pro- and synbiotics in the restoration of healthy gut microbia is described in detail to provide future directions for research.

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          Author and article information

          Journal
          Int Urol Nephrol
          International urology and nephrology
          Springer Nature
          1573-2584
          0301-1623
          Feb 2018
          : 50
          : 2
          Affiliations
          [1 ] Faculty of Foreign Languages and Cultures, Kunming University of Science and Technology, Kunming, Yunnan, China.
          [2 ] Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan, China. 657151276@qq.com.
          [3 ] Genetics and Pharmacogenomics Laboratory, Kunming University of Science and Technology, Kunming, Yunnan, China. 657151276@qq.com.
          Article
          10.1007/s11255-017-1689-5
          10.1007/s11255-017-1689-5
          28849345
          dee1daff-1f12-46a1-85ba-b44e5e139eca
          History

          Chronic kidney disease (CKD),Uremic toxins,Probiotics,Prebiotic,Lipopolysaccharides (LPS),Intestinal microbiota,Immune deregulation

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