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      Effects of Dexamethasone Before and After Puberty on the Daily Corticosterone Rhythm

      Neuroendocrinology

      S. Karger AG

      Dexamethasone, Adrenal rhythm, Puberty, Corticosterone, Stress

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          Abstract

          Female Sprague-Dawley-derived rats were injected at 25 days of age (pre-pubertal) or 60 days of age (adult) with 1 µg dexamethasone/100 g b.w. either before the beginning of the daily rise in serum corticosterone (at 10.00 or l2.OOh in adults and 10.00 h in prepubertal rats) or after the daily rise had begun (at 14.00 h in adults, and 12.00 or 14.00 h in prepubertal rats). Blood samples were collected by decapitation at 16.00, 20.00 and 24.00 h on that day and 04.00, 08.00 and 16.00 h the following day. In adults, dexamethasone (DEX) given at 10.00 shifted the corticosterone (B) peak to 20.00 from the control peak at 16.00 h. DEX at 12.00 or 14.00 h shifted the peak to 04.00. In prepubertal rats, DEX given before the B rise did not shift the subsequent peak and the pattern of B did not diverge from controls. DEX given at 12.00 or 14.00 shifted the peak to 24.00 h. At 08.00 the next day, B was depressed in adults but normal in prepubertal rats. At 16.00 h, both age groups showed depressed B in comparison to controls. Prepubertal rats appear to respond differently to dexamethasone than do adults.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1975
          1975
          20 March 2008
          : 17
          : 3
          : 203-210
          Affiliations
          Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebr.
          Article
          122356 Neuroendocrinology 1975;17:203–210
          10.1159/000122356
          1143619
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
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          Paper

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