For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
15
views
21
references
 Top references
cited by
62
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      323
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with the pathophysiology of major depressive disorder (MDD). In this mini review, we explored the association between BDNF and MDD using meta-analytic evidence. Our findings indicated that the Val66Met polymorphism in the BDNF gene was not associated with MDD or hippocampal volume in patients with MDD. However, plasma/serum levels of BDNF were decreased in patients with acute MDD compared with healthy controls. Both antidepressant treatment and electroconvulsive therapy increased plasma and serum levels of BDNF in patients with MDD. Val66Met polymorphism in the BDNF gene was associated with an antidepressant response in patients with MDD. Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD. However, peripheral BDNF levels are decreased in patients with MDD, and the polymorphisms are associated with treatment response. In conclusion, BDNF is best understood to be a biomarker for the state of MDD and its treatment response rather than a risk factor for MDD.

          Related collections

          Most cited references21

          • Record: found
          • Abstract: not found
          • Article: not found

          The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

          Michael Egan, Masami Kojima, Joseph Callicott … (2003)
          Article 0 comments Cited 475 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The impact of age, weight and gender on BDNF levels in human platelets and plasma.

            Marek Lommatzsch, Doerte Zingler, Katharina Schuhbaeck … (2005)
            Brain-derived neurotrophic factor (BDNF) is a key mediator of neuronal plasticity in the adult. BDNF is known to be stored in human platelets and to circulate in plasma, but the regulation and function of BDNF in peripheral blood is still poorly understood. In this prospective study, we have examined 140 healthy, non-allergic adults (20-60 years old) to elucidate the impact of age and physical parameters on BDNF levels in human platelets and plasma. There was a wide concentration range of BDNF in serum (median: 22.6 ng/ml), platelets (median: 92.7 pg/10(6) platelets) and plasma (median: 92.5 pg/ml). BDNF levels in plasma decreased significantly with increasing age or weight, whereas platelet levels did not. When matched for weight, there were no significant gender differences regarding BDNF plasma levels. However, women displayed significantly lower platelet BDNF levels than men. In addition, platelet BDNF levels changed during the menstrual cycle. In conclusion, we demonstrate that parameters such as age or gender have a specific impact on stored and circulating BDNF levels in peripheral blood.
            Article 0 comments Cited 230 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis.

              Maryna Polyakova, Katharina Stuke, Katharina Schuemberg … (2015)
              Peripheral brain-derived neurotrophic factor (BDNF) is decreased in acute major depressive disorder (MDD) and bipolar disorder (BD) and recovered after treatment. Here we validated on a meta-analytical level whether BDNF restores differentially according to treatment response and whose measurements could be used as a biomarker, plasma or serum.
              Article 0 comments Cited 163 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Psychiatry
                Journal ID (iso-abbrev): Front Psychiatry
                Journal ID (publisher-id): Front. Psychiatry
                Title: Frontiers in Psychiatry
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 1664-0640
                Publication date (Electronic): 17 January 2018
                Publication date Collection: 2017
                Volume: 8
                Electronic Location Identifier: 308
                Affiliations
                [1] 1Department of Psychiatry, School of Medicine, Fujita Health University , Toyoake, Japan
                [2] 2Department of Psychiatry, University of Occupational and Environmental Health , Kitakyushu, Japan
                [3] 3Department of Communication Sciences and Disorders, School of Applied Sciences, University of Mississippi , University, MS, United States
                Author notes

                Edited by: Cristina Cadoni, Consiglio Nazionale Delle Ricerche (CNR), Italy

                Reviewed by: Emma Sprooten, Icahn School of Medicine at Mount Sinai, United States; Britta Haenisch, Deutsche Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE), Germany

                *Correspondence: Taro Kishi, tarok@ 123456fujita-hu.ac.jp

                †These authors have contributed equally to this work.

                Specialty section: This article was submitted to Behavioral and Psychiatric Genetics, a section of the journal Frontiers in Psychiatry

                Article
                DOI: 10.3389/fpsyt.2017.00308
                PMC ID: 5776079
                PubMed ID: 29387021
                SO-VID: dee924e1-1dc1-4c7d-98ce-edfc302afed3
                Copyright © Copyright © 2018 Kishi, Yoshimura, Ikuta and Iwata.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 08 November 2017
                Date accepted : 22 December 2017
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 29, Pages: 5, Words: 3739
                Categories
                Subject: Psychiatry
                Subject: Mini Review

                ScienceOpen disciplines: Clinical Psychology & Psychiatry
                Keywords: brain-derived neurotrophic factor,pathophysiology,major depressive disorder,umbrella review,meta-analysis
                Data availability:
                ScienceOpen disciplines: Clinical Psychology & Psychiatry
                Keywords: brain-derived neurotrophic factor, pathophysiology, major depressive disorder, umbrella review, meta-analysis

                Comments

                Comment on this article

                scite_

                Similar content323

                See all similar

                Cited by60

                See all cited by

                Most referenced authors297

                See all reference authors