Direct Hypotensive Action of Intravascular Bradykinin in Man

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Abstract

To investigate the cardiovascular effects of bradykinin (BK), the peptide was injected into 6 normotensive volunteers in the supine position. BK was given intravenously as a bolus in a dose of 0.001–7.5 µg BK/kg body weight. Intraarterial blood pressure decreased dose related in a range of 0.25–1.0 µg BK/kg body weight. Pretreatment with 2 × 50 mg indomethacin or 80 mg propranolol as well as changes in oral salt intake (from 10 to 300 mmol NaVday) had no effect on the blood pressure-lowering effect of BK. Captopril (25 mg) potentiated the effect of BK 20- to 50-fold. In primary hyperaldosteronism, renal kallikrein activity and absolute vascular reaction to BK was increased. The results showed clearly that in man, similarly as in rats, BK lowers blood pressure by direct vasodilation and acts independently of prostaglandins, β-receptors or salt intake.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISBN: 978-3-8055-4079-7

ISBN: 978-3-318-00139-6

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 11 November 2008

Volume: 72

Issue: Suppl 1

Pages: 190-193

Affiliations

Medizinische Klinik Merheim, Universität Köln, BRD

Article

Publisher ID: 173973 Other ID: Cardiology 1985;72:190–193

DOI: 10.1159/000173973

PubMed ID: 2996767

SO-VID: deeaf464-c59f-49ea-98d1-5886ae12649c

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Direct Hypotensive Action of Intravascular Bradykinin in Man

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Karger: Cardiovascular System

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