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      Dietary fat and cholesterol and risk of cardiovascular disease in older adults: the Health ABC Study.

      Nutrition, Metabolism, and Cardiovascular Diseases
      Aged, Blood Glucose, analysis, Body Composition, Cardiovascular Diseases, etiology, Cholesterol, Dietary, administration & dosage, adverse effects, Diabetes Mellitus, Type 2, complications, Eggs, Female, Follow-Up Studies, Humans, Interviews as Topic, Male, Nutrition Assessment, Pennsylvania, Proportional Hazards Models, Prospective Studies, Questionnaires, Risk Factors, Self Report, Tennessee

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          Although dietary fats and cholesterol have previously been associated with risk of cardiovascular disease (CVD) in middle-aged populations, less is known among older adults. The purpose of this study was to determine the association between dietary fats, cholesterol, and eggs and CVD risk among community-dwelling adults aged 70-79 in the Health, Aging and Body Composition Study. Diet was assessed using an interviewer-administered 108-item food frequency questionnaire (n=1941). CVD events were defined as a confirmed myocardial infarction, coronary death, or stroke. Relative rates of CVD over 9 years of follow-up were estimated using Cox proportional hazards models. During follow-up, there were 203 incident cases of CVD. There were no significant associations between dietary fats and CVD risk. Dietary cholesterol (HR (95% CI): 1.47 (0.93, 2.32) for the upper vs. lower tertile; P for trend, 0.10) and egg consumption (HR (95% CI): 1.68 (1.12, 2.51) for 3+/week vs. <1/week; P for trend, 0.01) were associated with increased CVD risk. However, in sub-group analyses, dietary cholesterol and egg consumption were associated with increased CVD risk only among older adults with type 2 diabetes (HR (95% CI): 3.66 (1.09, 12.29) and 5.02 (1.63, 15.52), respectively, for the upper vs. lower tertile/group). Dietary cholesterol and egg consumption were associated with increased CVD risk among older, community-dwelling adults with type 2 diabetes. Further research on the biological mechanism(s) for the increased CVD risk with higher dietary cholesterol and frequent egg consumption among older adults with diabetes is warranted. Copyright © 2009 Elsevier B.V. All rights reserved.

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