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11-Oxoaerothionin: A Cytotoxic Antitumor Bromotyrosine-Derived Alkaloid from the Caribbean Marine Sponge Aplysina lacunosa
July 1992
July 1992
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Abstract
A new cytotoxic bromotyrosine-derived secondary metabolite, 11-oxoaerothionin [3],
was isolated from the Caribbean sea sponge Aplysina lacunosa. The structure of 3 was
argued on the basis of detailed spectroscopic analysis and by chemical conversion
to the known antibiotic compound 11-hydroxyaerothionin [2]. When screened against
a panel of four human cell lines, 11-oxoaerothionin [3] showed pronounced as well
as selective antitumor activity toward the human colon (HCT 116) cell line within
the limited concentration range of 0.01-0.1 microgram/ml.