Histological study of the nasal cavities and upper maxillae of Arvicanthis niloticus
naturally infected with Trichosomoides nasalis shows that the female worms reside
in the epithelial monolayer of the nasal mucosa of the posterior and median cavities.
Eggs laid by T. nasalis were infiltrated between the female body wall and the epithelial
lining. Small groups of eggs, mixed with mucus and polymorphonuclear cells, were found
in the nasal lumen, freed by rupture of the stretched epithelium. Two females and
a few eggs were also found in the connective tissues. One male was found in a female
uterus and two were apparently in the lumen of the nasal cavity but the surrounding
tissues were disrupted. No male was identified in the lamina propria of the mucosa.
However, significant inflammatory lesions occurred in the lamina propria, similar
to those induced by the males of Anatrichosoma spp. which live in this part of the
mucosa. In rodents, the lesions resulted in rhinosinusitis characterised by a lymphocytic
infiltration leading to nasal obstruction.