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      Immune response and reactogenicity of intradermal administration versus subcutaneous administration of varicella-zoster virus vaccine: an exploratory, randomised, partly blinded trial.

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          Abstract

          The licensed live, attenuated varicella-zoster virus vaccine prevents herpes zoster in adults older than 50 years. We aimed to determine whether intradermal administration of zoster vaccine could enhance vaccine immunogenicity compared with conventional needle subcutaneous administration.

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          Author and article information

          Journal
          Lancet Infect Dis
          The Lancet. Infectious diseases
          Elsevier BV
          1474-4457
          1473-3099
          August 2016
          : 16
          : 8
          Affiliations
          [1 ] Merck & Co, Kenilworth, NJ, USA. Electronic address: chanbeals@gmail.com.
          [2 ] Merck & Co, Kenilworth, NJ, USA.
          [3 ] NanoPass Technologies Ltd, Nes Ziona, Israel.
          [4 ] Miami Research Associates, Miami, FL, USA.
          [5 ] Clinical Pharmacology of Miami, Miami, FL, USA.
          [6 ] Pediatric Infectious Diseases, University of Colorado, Denver Anschutz Medical Campus, Aurora, CO, USA.
          Article
          S1473-3099(16)00133-X
          10.1016/S1473-3099(16)00133-X
          27061887

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