21
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      The Effect of Plasma Cortisol Concentration on the Pituitary Adrenal Response Elicited by Electrical Stimulation of the Infundibular Area of the Awake Unrestrained Cat

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A non stressful environment was established for awake unrestrained cats to test the excitability of infundibular area sites mediating ACTH release. Each subject was chronically implanted with bilateral electrodes and catheterized in the superior vena cava. Plasma corticosterone and cortisol concentration were determined by fluorometry after chromatographic separation. Samples were taken during both sham and electrical stimulation while the subjects, of their own volition, reclined in a tray. Control samples collected early in the 3-month experimental period showed cortisol values as high as the cortisol response to ACTH. Repetition of the control sampling procedure produced low cortisol levels. No discernible change in the cats’ overt behavior accompanied this decrease in cortisol. Electrical stimulation, which produced a rise in plasma cortisol, did not necessarily result in an overt behavioral reaction. When control cortisol values were high, stimulation was followed by no change or a decrease in cortisol concentration; when cortisol values were low it resulted in increased cortisol concentration. The excitatory influence of infundibular stimulation on cortisol was confirmed under barbiturate anesthesia. It is concluded that electrical stimulation of the infundibular area maximally elevates cortisol when control values are low. Repeated training lowers initially high cortisol levels.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1974
          1974
          21 November 2008
          : 5
          : 3
          : 173-181
          Affiliations
          Departments of Physiology and Psychology, University of Pittsburgh, Pittsburgh, Pa.
          Article
          178628 Horm Res 1974;5:173–181
          10.1159/000178628
          4366050
          df3e19a7-6cbc-452b-b13f-fc320aec9ea9
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 9
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Infundibular area stimulation,Hypothalamo-pituitary-adrenal system,Sympathetic response,Plasma cortisol and corticosterone,ACTH,Chronically implanted electrodes,Steroid negative feedback inhibition,Novelty stimulation

          Comments

          Comment on this article