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A novel polymer-coated adsorbent (subtractive adsorbent) has been manufactured and
evaluated for the recovery of nanoparticle bioproducts. The core principle was to
coat inert macroporous polymers (e.g. agarose) upon adsorbent beads of varied ligands.
Here BSA nanoparticles, with an average nanoparticle diameter 95 nm, were fabricated
and selected as feedstock for the demonstration of the principle. The adsorption of
a mixture of fluorescently labelled BSA solution and BSA nanoparticles was investigated
in a batch binding experiment upon polymer-coated Streamline DEAE and visualised by
laser scanning confocal microscopy. The mechanistic design of such adsorbents and
their basic application for the recovery of target nano-bioproducts from complex feedstock
is strongly indicated.