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      Structural Investigation of a Self-Cross-Linked Chitosan/Alginate Dialdehyde Multilayered Film with in Situ QCM-D and Spectroscopic Ellipsometry

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      Author(s): , ,
      Publication date (Electronic):
      Journal: ACS Omega
      Publisher: American Chemical Society

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          Abstract

          A chitosan/alginate dialdehyde multilayered film was fabricated using the layer-by-layer assembly method. Besides electrostatic interaction that promotes alternate adsorption of the oppositely charged polyelectrolytes, the Schiff base reaction between the amine groups on chitosan and the aldehyde groups on alginate dialdehyde provides a covalently cross-linked film, which after reduction by sodium cyanoborohydride is stable under both acidic and alkaline conditions. Moreover, the cross-linked film is responsive to changes in pH and addition of multivalent salts. The structural properties of the multilayered film such as thickness, refractive index, and water content were examined using simultaneous quartz crystal microbalance with dissipation monitoring and spectroscopic ellipsometry.

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          Interactions between alginate and chitosan biopolymers characterized using FTIR and XPS.

          Stanley A. Temple, G Lawrie, Tara Rintoul … (2007)
          This study investigates alginate-chitosan polyelectrolyte complexes (PECs) in the form of a film, a precipitate, as well as a layer-by-layer (LbL) assembly. The focus of this study is to fully characterize, using the complementary techniques of Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) in combination with solution stability evaluation, the interactions between alginate and chitosan in the PECs. In the FTIR spectra, no significant change in the band position of the two carbonyl vibrations from alginate occurs upon interaction with different ionic species. However, protonation of the carboxylate group causes a new band to appear at 1710 cm(-1), as anticipated. Partial protonation of the amine group of chitosan causes the appearance of one new band ( approximately 1530 cm(-1)) due to one of the -NH3+ vibrational modes (the other mode overlaps the amide I band). Importantly, the position of the two main bands in the spectral region of interest in partly protonated chitosan films is not dependent on the extent of protonation. XPS N 1s narrow scans can, however, be used to assess the degree of amine protonation. In our alginate-chitosan film, precipitate, and LbL assembly, the bands observed in the FTIR correspond to the species -COO- and -NH3+, but their position is not different from each of the single components. Thus, the conclusion of the study is that FTIR cannot be used directly to identify the presence of PECs. However, in combination with XPS (survey and narrow N 1s scans) and solution stability evaluation, a more complete description of the structure can be obtained. This conclusion challenges the assignment of FTIR spectra in the literature.
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            Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure-Activity Relationship.

            Priyanka Sahariah, Már Másson (2017)
            This review gives an updated overview of the current state-of-the-art for antimicrobial chitosan and chitosan derivatives and the effects of structural modifications on activity and toxicity. The various synthetic routes introduced for chemical modification of chitosan are discussed, and the most common functional groups are highlighted. Different analytical techniques used for structural characterization of the synthesized chitosan derivatives are discussed and critically evaluated. For the purpose of this review, the antimicrobial chitosan derivatives have been classified on the basis of the type of functional group conjugated to the polymer backbone. In each case, the influence of the degree of substitution on the biological properties has been examined. Finally, we have summarized the collective information and suggested future directions for further research to improve our understanding of the bioactivity and to develop more useful chitosan conjugates.
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              Chitosan-alginate hybrid scaffolds for bone tissue engineering.

              Zhensheng Li, Hassna Ramay, Kip Hauch … (2005)
              A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. Here we report on the development of a biodegradable porous scaffold made from naturally derived chitosan and alginate polymers with significantly improved mechanical and biological properties as compared to its chitosan counterpart. Enhanced mechanical properties were attributable to the formation of a complex structure of chitosan and alginate. Bone-forming osteoblasts readily attached to the chitosan-alginate scaffold, proliferated well, and deposited calcified matrix. The in vivo study showed that the hybrid scaffold had a high degree of tissue compatibility. Calcium deposition occurred as early as the fourth week after implantation. The chitosan-alginate scaffold can be prepared from solutions of physiological pH, which may provide a favorable environment for incorporating proteins with less risk of denaturation. Coacervation of chitosan and alginate combined with liquid-solid separation provides a scaffold with high porosity, and mechanical and biological properties suitable for rapid advancement into clinical trials.
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                Author and article information

                Journal
                Journal ID (nlm-ta): ACS Omega
                Journal ID (iso-abbrev): ACS Omega
                Journal ID (publisher-id): ao
                Journal ID (coden): acsodf
                Title: ACS Omega
                Publisher: American Chemical Society
                ISSN (Electronic): 2470-1343
                Publication date (Electronic): 25 January 2019
                Publication date Collection: 31 January 2019
                Volume: 4
                Issue: 1
                Pages: 2019-2029
                Affiliations
                [1]Department of Chemistry, Technical University of Denmark , Kemitorvet 206, 2800 Kgs. Lyngby, Denmark
                Author notes
                [* ]E-mail: esth@ 123456kemi.dtu.dk . Phone: (+45) 4525 2439.
                Article
                DOI: 10.1021/acsomega.8b03145
                PMC ID: 6648685
                PubMed ID: 31459453
                SO-VID: df639c2b-2eb3-4ab8-ae13-2e016b6bf3fe
                Copyright © Copyright © 2019 American Chemical Society
                License:

                This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

                History
                Date received : 11 November 2018
                Date accepted : 10 January 2019
                Categories
                Subject: Article
                Custom metadata
                document-id-old-9 ao8b03145
                document-id-new-14 ao-2018-03145u
                ccc-price

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