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      Structural Investigation of a Self-Cross-Linked Chitosan/Alginate Dialdehyde Multilayered Film with in Situ QCM-D and Spectroscopic Ellipsometry

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      American Chemical Society

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          Abstract

          A chitosan/alginate dialdehyde multilayered film was fabricated using the layer-by-layer assembly method. Besides electrostatic interaction that promotes alternate adsorption of the oppositely charged polyelectrolytes, the Schiff base reaction between the amine groups on chitosan and the aldehyde groups on alginate dialdehyde provides a covalently cross-linked film, which after reduction by sodium cyanoborohydride is stable under both acidic and alkaline conditions. Moreover, the cross-linked film is responsive to changes in pH and addition of multivalent salts. The structural properties of the multilayered film such as thickness, refractive index, and water content were examined using simultaneous quartz crystal microbalance with dissipation monitoring and spectroscopic ellipsometry.

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          Chitosan-alginate hybrid scaffolds for bone tissue engineering.

          A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. Here we report on the development of a biodegradable porous scaffold made from naturally derived chitosan and alginate polymers with significantly improved mechanical and biological properties as compared to its chitosan counterpart. Enhanced mechanical properties were attributable to the formation of a complex structure of chitosan and alginate. Bone-forming osteoblasts readily attached to the chitosan-alginate scaffold, proliferated well, and deposited calcified matrix. The in vivo study showed that the hybrid scaffold had a high degree of tissue compatibility. Calcium deposition occurred as early as the fourth week after implantation. The chitosan-alginate scaffold can be prepared from solutions of physiological pH, which may provide a favorable environment for incorporating proteins with less risk of denaturation. Coacervation of chitosan and alginate combined with liquid-solid separation provides a scaffold with high porosity, and mechanical and biological properties suitable for rapid advancement into clinical trials.
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            Interactions between alginate and chitosan biopolymers characterized using FTIR and XPS.

            This study investigates alginate-chitosan polyelectrolyte complexes (PECs) in the form of a film, a precipitate, as well as a layer-by-layer (LbL) assembly. The focus of this study is to fully characterize, using the complementary techniques of Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) in combination with solution stability evaluation, the interactions between alginate and chitosan in the PECs. In the FTIR spectra, no significant change in the band position of the two carbonyl vibrations from alginate occurs upon interaction with different ionic species. However, protonation of the carboxylate group causes a new band to appear at 1710 cm(-1), as anticipated. Partial protonation of the amine group of chitosan causes the appearance of one new band ( approximately 1530 cm(-1)) due to one of the -NH3+ vibrational modes (the other mode overlaps the amide I band). Importantly, the position of the two main bands in the spectral region of interest in partly protonated chitosan films is not dependent on the extent of protonation. XPS N 1s narrow scans can, however, be used to assess the degree of amine protonation. In our alginate-chitosan film, precipitate, and LbL assembly, the bands observed in the FTIR correspond to the species -COO- and -NH3+, but their position is not different from each of the single components. Thus, the conclusion of the study is that FTIR cannot be used directly to identify the presence of PECs. However, in combination with XPS (survey and narrow N 1s scans) and solution stability evaluation, a more complete description of the structure can be obtained. This conclusion challenges the assignment of FTIR spectra in the literature.
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              Stimuli-responsive hydrogel thin films

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                Author and article information

                Journal
                ACS Omega
                ACS Omega
                ao
                acsodf
                ACS Omega
                American Chemical Society
                2470-1343
                25 January 2019
                31 January 2019
                : 4
                : 1
                : 2019-2029
                Affiliations
                [1]Department of Chemistry, Technical University of Denmark , Kemitorvet 206, 2800 Kgs. Lyngby, Denmark
                Author notes
                [* ]E-mail: esth@ 123456kemi.dtu.dk . Phone: (+45) 4525 2439.
                Article
                10.1021/acsomega.8b03145
                6648685
                df639c2b-2eb3-4ab8-ae13-2e016b6bf3fe
                Copyright © 2019 American Chemical Society

                This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

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                ao8b03145
                ao-2018-03145u

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