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      Ocular hypotensive action of ergoline derivatives in rabbits: effects of sympathectomy and domperidone pretreatment

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      Current Eye Research
      Informa UK Limited

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          Inhibition by dopamine of 3H-noradrenaline release elicited by nerve stimulation in the isolated cat's nictitating membrane

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            Bromocriptine inhibits norepinephrine release.

            Bromocriptine is a dopamine agonist that induces postural hypotension and can be used as an antihypertensive. The drug inhibits release of norepinephrine (NE) from an isolated artery by stimulating presynaptic receptors. In normotensive subjects it lowers both plasma and cerebrospinal fluid (CSF) levels of NE by 50% and lowers blood pressure moderately in standing subjects and slightly in recumbent subjects. Through central and peripheral mechanisms, bromocriptine inhibits sympathetic nervous discharge of NE.
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              Effect of Timolol on Aqueous Humor Dynamics in the Rabbit

              The effects of timolol and several reference agents upon intraocular pressure (IOP), outflow facility and aqueous humor formation, were investigated in rabbits. Consistent with their proposed mechanisms of action, norepinephrine and epinephrine (1% topically) lowered IOP and increased outflow facility, whereas, acetazolamide (100 mg/kg i.v.) and isoproterenol (1 % topically) lowered IOP without affecting outflow facility. At the same doses, acetazolamide, but not epinephrine, reduced aqueous humor formation. Timolol (1 % topically) reduced IOP, reduced aqueous humor flow and did not alter outflow facility. The data suggest that in rabbits, as in man, timolol lowers IOP primarily by reducing the formation of aqueous humor.
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                Author and article information

                Journal
                Current Eye Research
                Current Eye Research
                Informa UK Limited
                0271-3683
                1460-2202
                July 02 2009
                January 1984
                July 02 2009
                January 1984
                : 3
                : 2
                : 307-314
                Article
                10.3109/02713688408997214
                df671a4e-b546-46f5-96ba-af593a94f7e3
                © 1984
                History

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