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      Cell-Based Bone Tissue Engineering

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      Author(s): * , , ,  
      Publication date (Electronic):
      Journal: PLoS Medicine
      Publisher: Public Library of Science

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          Abstract

          The authors review the available data on bone tissue engineering and discuss possible new research areas that could help to make bone tissue engineering a clinical success.

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          Most cited references60

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          Engineering vascularized skeletal muscle tissue.

          Shulamit Levenberg, Jeroen Rouwkema, Mara Macdonald … (2005)
          One of the major obstacles in engineering thick, complex tissues such as muscle is the need to vascularize the tissue in vitro. Vascularization in vitro could maintain cell viability during tissue growth, induce structural organization and promote vascularization upon implantation. Here we describe the induction of endothelial vessel networks in engineered skeletal muscle tissue constructs using a three-dimensional multiculture system consisting of myoblasts, embryonic fibroblasts and endothelial cells coseeded on highly porous, biodegradable polymer scaffolds. Analysis of the conditions for induction and stabilization of the vessels in vitro showed that addition of embryonic fibroblasts increased the levels of vascular endothelial growth factor expression in the construct and promoted formation and stabilization of the endothelial vessels. We studied the survival and vascularization of the engineered muscle implants in vivo in three different models. Prevascularization improved the vascularization, blood perfusion and survival of the muscle tissue constructs after transplantation.
          Article 0 comments Cited 233 times – based on 0 reviews     Review now
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            Tissue-engineered bone regeneration.

            H Petite, V Viateau, W Bensaïd … (2000)
            Bone lesions above a critical size become scarred rather than regenerated, leading to nonunion. We have attempted to obtain a greater degree of regeneration by using a resorbable scaffold with regeneration-competent cells to recreate an embryonic environment in injured adult tissues, and thus improve clinical outcome. We have used a combination of a coral scaffold with in vitro-expanded marrow stromal cells (MSC) to increase osteogenesis more than that obtained with the scaffold alone or the scaffold plus fresh bone marrow. The efficiency of the various combinations was assessed in a large segmental defect model in sheep. The tissue-engineered artificial bone underwent morphogenesis leading to complete recorticalization and the formation of a medullary canal with mature lamellar cortical bone in the most favorable cases. Clinical union never occurred when the defects were left empty or filled with the scaffold alone. In contrast, clinical union was obtained in three out of seven operated limbs when the defects were filled with the tissue-engineered bone.
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              Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers.

              A Gerasimov, A Y Friedenstein, R K Chailakhyan (1987)
              Fibroblast colonies (clones) were obtained by explantation of bone marrow single-cell suspensions and were used to establish multicolony and single-colony derived fibroblast cultures by successive passaging of either pooled or individual colonies. When transplanted in diffusion chambers after 20-30 cell doublings in vitro, the descendants of fibroblast colony-forming cells (FCFC), whether grown from single or pooled colonies, retained the ability for bone and cartilage formation. The content of osteogenic precursors in the cultured progeny significantly outnumbered the initiating FCFC. Thus the high proliferative potential of bone marrow FCFC and their ability to serve as common precursors of bone and cartilage-forming cells makes them probable candidates for the role of osteogenic stem cells.
              Article 0 comments Cited 168 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): PLoS Med
                Journal ID (publisher-id): pmed
                Title: PLoS Medicine
                Publisher: Public Library of Science (San Francisco, USA )
                ISSN (Print): 1549-1277
                ISSN (Electronic): 1549-1676
                Publication date (Print): February 2007
                Publication date (Electronic): 20 February 2007
                Volume: 4
                Issue: 2
                Electronic Location Identifier: e9
                Author notes
                * To whom correspondence should be addressed. E-mail: drgjmeijer@ 123456wanadoo.nl
                Article
                Publisher ID: 06-PLME-RIT-0352R2
                DOI: 10.1371/journal.pmed.0040009
                PMC ID: 1800310
                PubMed ID: 17311467
                SO-VID: df743098-84f4-4892-8286-9288b8b75daf
                Copyright © Copyright: © 2007 Meijer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
                History
                Page count
                Pages: 5
                Categories
                Subject: Research in Translation
                Subject: Biotechnology
                Subject: Biotechnology
                Subject: Cell Biology
                Subject: Public Health and Epidemiology
                Subject: Rheumatology
                Subject: Rheumatology
                Subject: Orthopedic and Trauma Surgery
                Subject: Rheumatology
                Subject: Plastic and Reconstructive Surgery
                Subject: Rehabilitation Medicine
                Subject: Surgery
                Custom metadata
                citation Meijer GJ, de Bruijn JD, Koole R, van Blitterswijk CA (2007) Cell-based bone tissue engineering. PLoS Med 4(2): e9. doi: 10.1371/journal.pmed.0040009

                ScienceOpen disciplines: Medicine
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                ScienceOpen disciplines: Medicine

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