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      Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases

      1 , 2 , 1 , 2 , 3 , 1

      Annual Review of Nutrition

      Annual Reviews

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          Abstract

          Molecular clocks are present in almost every cell to anticipate daily recurring and predictable changes, such as rhythmic nutrient availability, and to adapt cellular functions accordingly. At the same time, nutrient-sensing pathways can respond to acute nutrient imbalance and modulate and orient metabolism so cells can adapt optimally to a declining or increasing availability of nutrients. Organismal circadian rhythms are coordinated by behavioral rhythms such as activity–rest and feeding–fasting cycles to temporally orchestrate a sequence of physiological processes to optimize metabolism. Basic research in circadian rhythms has largely focused on the functioning of the self-sustaining molecular circadian oscillator, while research in nutrition science has yielded insights into physiological responses to caloric deprivation or to specific macronutrients. Integration of these two fields into actionable new concepts in the timing of food intake has led to the emerging practice of time-restricted eating. In this paradigm, daily caloric intake is restricted to a consistent window of 8–12 h. This paradigm has pervasive benefits on multiple organ systems.

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          Author and article information

          Journal
          Annual Review of Nutrition
          Annu. Rev. Nutr.
          Annual Reviews
          0199-9885
          1545-4312
          June 10 2019
          August 21 2019
          June 10 2019
          August 21 2019
          : 39
          : 1
          Affiliations
          [1 ]Regulatory Biology Lab, Salk Institute for Biological Studies, La Jolla, California 92037, USA;
          [2 ]These authors contributed equally to this article
          [3 ]Molecular Biology Program and Heart Institute, Department of Biology, San Diego State University, San Diego 92182, California, USA
          Article
          10.1146/annurev-nutr-082018-124320
          © 2019

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