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      Potential rules of anesthetic gases on glioma

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Glioma is one of the most frequent primary brain tumors. Currently, the most common therapeutic strategy for patients with glioma is surgical resection combined with radiotherapy or/and adjuvant chemotherapy. However, due to the metastatic and invasive nature of glioma cells, the recurrence rate is high, resulting in poor prognosis. In recent years, gas therapy has become an emerging treatment. Studies have shown that the proliferation, metastasis and invasiveness of glioma cells exposed to anesthetic gases are obviously inhibited. Therefore, anesthetic gas may play a special therapeutic role in gliomas. In this review, we aim to collect existing research and summarize the rules of using anesthetic gases on glioma, providing potential strategies for further clinical treatment.

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          The functions of animal microRNAs.

          Victor Ambros (2004)
          MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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            Nitric oxide signalling in cardiovascular health and disease

            Jean-Luc Balligand, Lauriane Michel, Charlotte Farah (2018)
            Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in cardiovascular homeostasis. Tremendous knowledge has been accumulated on the mechanisms of the nitric oxide synthase (NOS)-NO pathway, but how this highly reactive, free radical gas signals to specific targets for precise regulation of cardiovascular function remains the focus of much intense research. In this Review, we summarize the updated paradigms on NOS regulation, NO interaction with reactive oxidant species in specific subcellular compartments, and downstream effects of NO in target cardiovascular tissues, while emphasizing the latest developments of molecular tools and biomarkers to modulate and monitor NO production and bioavailability.
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              Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity.

              Menotti Calvani, Cesare Mancuso, Enrico Rizzarelli … (2007)
              At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
              Article 0 comments Cited 192 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Med Gas Res
                Journal ID (iso-abbrev): Med Gas Res
                Journal ID (publisher-id): MGR
                Title: Medical Gas Research
                Publisher: Wolters Kluwer - Medknow (India )
                ISSN (Electronic): 2045-9912
                Publication date Collection: Jan-Mar 2020
                Publication date (Electronic): 13 March 2020
                Volume: 10
                Issue: 1
                Pages: 50-53
                Affiliations
                [1]Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
                Author notes
                [* ]Correspondence to: Zheng-Quan Yu, zhengquan_yu@ 123456126.com ; Jiang Wu, szjiangwu@ 123456163.com .

                Author contributions

                Manuscript writing: XC; manuscript revision: YGM; review design: ZQY, JW, GC. All the authors read and approved the final version of the manuscript for publication.

                [#]

                These authors contributed equally to this work.

                Author information
                http://orcid.org/0000-0002-8336-0436
                Article
                Publisher ID: MGR-10-50
                DOI: 10.4103/2045-9912.279984
                PMC ID: 7871937
                PubMed ID: 32189670
                SO-VID: df8832b5-72fd-4bf1-aabf-ae8a865fb131
                Copyright © Copyright: © 2020 Medical Gas Research
                License:

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                Date received : 08 August 2019
                Date revision received : 12 August 2019
                Date accepted : 12 September 2019
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular medicine
                Keywords: anesthetic gases,glioma,invasion,isoflurane,metastasis,proliferation,sevoflurane
                Data availability:
                ScienceOpen disciplines: Molecular medicine
                Keywords: anesthetic gases, glioma, invasion, isoflurane, metastasis, proliferation, sevoflurane

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