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      Evaluation of Commercially Available Anti–Dengue Virus Immunoglobulin M Tests

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          Abstract

          Anti–dengue virus immunoglobulin M kits were evaluated. Test sensitivities were 21%–99% and specificities were 77%–98% compared with reference ELISAs. False-positive results were found for patients with malaria or past dengue infections. Three ELISAs showing strong agreement with reference ELISAs will be included in the World Health Organization Bulk Procurement Scheme.

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          Most cited references9

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          Dengue in the early febrile phase: viremia and antibody responses.

          S. Nimmannitya, David W Vaughn, A. Nisalak … (1997)
          A multicenter effort was begun in 1994 to characterize the pathophysiology of dengue using a study design that minimized patient selection bias by offering enrollment to all children with undifferentiated fever for <72 h. In the first year, 189 children were enrolled (age range, 8 months to 14 years). Thirty-two percent of these children had dengue infections (60 volunteers). The percentage of children with a secondary dengue infection was 93%, with only 4 (7%) having a primary dengue infection. The virus isolation rate from the plasma of children with dengue was 98%. Viremia correlated highly with temperature. All four dengue virus serotypes were isolated at both study sites. This study demonstrates that all four serotypes of dengue virus can cause dengue hemorrhagic fever, that all dengue patients as defined by serology experience viremia during the febrile phase, and that as fever subsides, so does viremia.
          Article 0 comments Cited 102 times – based on 0 reviews     Review now
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            Dengue diagnosis, advances and challenges.

            María G Guzmán, Gustavo Kouri (2004)
            Dengue diagnosis was one of the topics discussed at the symposium 'The Global Threat of Dengue - Desperately Seeking Solutions' organized during the 10th International Congress of Infectious Diseases held in Singapore in 2002. In this paper, a review is presented focusing on the main advances, problems and challenges of dengue diagnosis.IgM capture ELISA, virus isolation in mosquito cell lines and live mosquitoes, dengue specific monoclonal antibodies and PCR have all represented major advances in dengue diagnosis. However, an appropriate rapid, early and accessible diagnostic method useful both for epidemiological surveillance and clinical diagnosis is still needed. Also, tools that suggest a prognosis allowing for better management are also needed. Finally, laboratory infrastructure, technical expertise and research capacity must be improved in endemic countries in order to positively influence dengue surveillance, clinical case management and the development of new approaches to dengue control.
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              Severe dengue virus infection in travelers: risk factors and laboratory indicators.

              Ole Wichmann, Joaquim Gascon, Mirjam Schunk … (2007)
              Dengue fever is the most common arboviral disease in travelers. In countries where dengue virus is endemic, sequential (secondary) infections with different dengue virus serotypes are associated with disease severity. Data on severity and secondary infection rates in a population of travelers are lacking. Intensified surveillance of dengue fever in travelers was performed within the European Network on Surveillance of Imported Infectious Diseases. Data were collected at 14 European clinical referral centers between 2003 and 2005. A total of 219 dengue virus infections imported from various regions of endemicity were reported. Serological analysis revealed a secondary immune response in 17%. Spontaneous bleeding was observed in 17 (8%) patients and was associated with increased serum alanine and aspartate aminotransferase levels and lower median platelet counts. Two (0.9%) patients fulfilled the World Health Organization (WHO) case definition for dengue hemorrhagic fever. However, 23 (11%) travelers had severe clinical manifestations (internal hemorrhage, plasma leakage, shock, or marked thrombocytopenia). A secondary immune response was significantly associated with both spontaneous bleeding and other severe clinical manifestations. In travelers, severe dengue virus infections are not uncommon but may be missed if the WHO classification is strictly applied. High liver enzyme levels and low platelet counts could serve as indicators of disease severity.
              Article 0 comments Cited 41 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): March 2009
                Volume: 15
                Issue: 3
                Pages: 436-439
                Affiliations
                [1]Centers for Disease Control and Prevention, San Juan, Puerto Rico, USA (E.A. Hunsperger, K.E. Bessoff)
                [2]Mahidol University, Bangkok, Thailand (S. Yoksan)
                [3]Institut Pasteur, Phnom Penh, Cambodia (P. Buchy)
                [4]Cho Quan Hospital, Ho Chi Minh City, Vietnam (V.C. Nguyen)
                [5]University of Malaya, Kuala Lumpur, Malaysia (S.D. Sekaran)
                [6]Instituto Nacional Enfermedades Virales Humanas Dr. Julio I. Maiztegui, Buenos Aires, Argentina (D.A. Enria)
                [7]Instituto Medicina Tropical Pedro Kouri, Havana, Cuba (S. Vázquez, M.G. Guzmán, J.L. Pelegrino)
                [8]Public Health Agency of Canada, Winnipeg, Manitoba, Canada (H. Artsob, M. Drebot)
                [9]University of Hawaii, Honolulu, Hawaii, USA (D.J. Gubler)
                [10]Pediatric Dengue Vaccine Initiative, Seoul, South Korea (S.B. Halstead, H.S. Margolis, S. Kliks)
                [11]World Health Organization, Geneva, Switzerland (C.-M. Nathanson, N.R. Rizzo, R.W. Peeling)
                Author notes
                Address for correspondence: Rosanna W. Peeling, Special Programme for Research and Training in Tropical Diseases, World Health Organization, 20 Ave Appia, Geneva, Switzerland; email: peelingr@ 123456who.int
                Article
                Publisher ID: 08-0923
                DOI: 10.3201/eid1503.080923
                PMC ID: 2681117
                PubMed ID: 19239758
                SO-VID: df9b2fc1-9a01-41e0-8723-d7f3faacf7a2
                History
                Categories
                Subject: Dispatch

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: elisa,immunoglobulin m,dispatch,dengue fever,diagnostic test
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: elisa, immunoglobulin m, dispatch, dengue fever, diagnostic test

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