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      Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction

      , 1 , 1

      Reproductive biology and endocrinology : RB&E

      BioMed Central

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          Abstract

          Capacitation is an important physiological pre-requisite before the sperm cell can acrosome react and fertilize the oocyte. Recent reports from several laboratories have amply documented that the protein phosphorylation especially at tyrosine residues is one of the most important events that occur during capacitation. In this article, we have reviewed the data from our and other laboratories, and have constructed a heuristic model for the mechanisms and molecules involved in capacitation/acrosome reaction.

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          Most cited references 128

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          Signaling--2000 and beyond.

           Jon Hunter (2000)
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            Fertilizing capacity of spermatozoa deposited into the fallopian tubes.

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              Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems.

               Tony Pawson (2004)
              Over the last two decades, a new and unifying concept of cellular organization has emerged in which modular protein-protein interactions provide an underlying framework through which signaling pathways are assembled and controlled. In this scheme, posttranslational modifications such as phosphorylation commonly exert their biological effects by regulating molecular interactions, exemplified by the ability of phosphotyrosine sites to bind selectively to SH2 domains. Although these interactions are rather simple in isolation, they can nonetheless be exploited to generate complex cellular systems. Here, I discuss experiments that have led to this view of dynamic cellular behavior and identify some current and future areas of interest in cell signaling.
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                Author and article information

                Journal
                Reprod Biol Endocrinol
                Reproductive biology and endocrinology : RB&E
                BioMed Central (London )
                1477-7827
                2004
                9 November 2004
                : 2
                : 75
                Affiliations
                [1 ]Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio, USA
                Article
                1477-7827-2-75
                10.1186/1477-7827-2-75
                533862
                15535886
                Copyright © 2004 Naz and Rajesh; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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                Human biology

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