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      Catalyst-free synthesis of high elongation degradable polyurethanes containing varying ratios of isosorbide and polycaprolactone: physical properties and biocompatibility.

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          Abstract

          Biocompatible and biodegradable polyurethanes were prepared with fixed aliphatic diisocyanate level and varying ratios of isosorbide, and PCL diol via a simple one-shot polymerization without a catalyst. The successful synthesis of the polyurethanes was confirmed by gel permeation chromatography, (1)H-nuclear magnetic resonance and Fourier transform-infrared spectroscopies and the thermal properties were determined by differential scanning calorimetry and showed glass transition temperatures of around 30-35 °C. The degradation tests were performed at 37 °C in phosphate buffer solution (approx. pH 7.3) and showed a mass loss of around 5 % after 12 weeks, except for the polymer with the highest isosorbide content which showed an initial rapid mass loss. The in vitro cytocompatibility test results following culture of osteoblasts on the polymer surface showed that relative cell number on all of the polyurethane films after 5 days of cultured on polymer films was lower compared to the proliferation rate on the optimized tissue culture plastic. These polymers offer significant promise due to the simplicity of the synthesis and the controlled degradation.

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          Author and article information

          Journal
          J Mater Sci Mater Med
          Journal of materials science. Materials in medicine
          1573-4838
          0957-4530
          Feb 2013
          : 24
          : 2
          Affiliations
          [1 ] Department of Nanobiomedical Science and WCU Research Center, Dankook University Graduate School, Chungnam, 330-714, South Korea.
          Article
          10.1007/s10856-012-4814-0
          23183961
          dfaa9e01-2ba5-4ead-9d04-1fbb7a34acd7
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