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      Neuroendocrine Status of Old Constant-Estrous Rats

      ,

      Neuroendocrinology

      S. Karger AG

      Constant estrus, LH, FSH, FSH-RF, Prolactin, PIF

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          Abstract

          Hypothalamic and pituitary functions of 21-month-old rats in constant estrus were compared with those of 3-month-old cycling rats on the day of estrus. FSH-RF in the hypothalamus and pituitary FSH were significantly higher in the old than in the young rats. Pituitary LH was significantly lower in the old than in the young rats. Hypothalamic PIF was similar in both groups, but pituitary prolactin concentration was significantly greater in the old rats. The old constant-estrous rats showed well-developed ovarian follicles but no corpora lutea, increased uterine weight, hyperplastic mammary glands, and increased pituitary weight. It is suggested that the constant estrus observed in many old female rats is the result of a fundamental change in hypothalamic control of pituitary FSH, LH, and prolactin secretion.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1971
          1971
          19 March 2008
          : 7
          : 4
          : 249-256
          Affiliations
          Department of Physiology, Michigan State University, East Lansing, Michigan
          Article
          121973 Neuroendocrinology 1971;7:249–256
          10.1159/000121973
          4927853
          © 1971 S. Karger AG, Basel

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          Pages: 8
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