Neuroendocrine Status of Old Constant-Estrous Rats

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Abstract

Hypothalamic and pituitary functions of 21-month-old rats in constant estrus were compared with those of 3-month-old cycling rats on the day of estrus. FSH-RF in the hypothalamus and pituitary FSH were significantly higher in the old than in the young rats. Pituitary LH was significantly lower in the old than in the young rats. Hypothalamic PIF was similar in both groups, but pituitary prolactin concentration was significantly greater in the old rats. The old constant-estrous rats showed well-developed ovarian follicles but no corpora lutea, increased uterine weight, hyperplastic mammary glands, and increased pituitary weight. It is suggested that the constant estrus observed in many old female rats is the result of a fundamental change in hypothalamic control of pituitary FSH, LH, and prolactin secretion.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1971

Publication date (Print): 1971

Publication date (Electronic): 19 March 2008

Volume: 7

Issue: 4

Pages: 249-256

Affiliations

Department of Physiology, Michigan State University, East Lansing, Michigan

Article

Publisher ID: 121973 Other ID: Neuroendocrinology 1971;7:249–256

DOI: 10.1159/000121973

PubMed ID: 4927853

SO-VID: dfaf2a17-3893-4c8f-99dc-078f8b60317d

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 05 August 1970

Date accepted : 11 September 1970

Page count

Pages: 8

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