Daily Rhythms in Cortisol and Melatonin in Primate Cerebrospinal Fluid

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Abstract

Cerebrospinal fluid was continuously collected from the cisternal-cervical subarachnoid space of chair-restrained rhesus monkeys. The concentrations of melatonin and cortisol were measured in the cerebrospinal fluid. Under diurnal lighting (light:dark, 12:12 h) melatonin concentrations were elevated during darkness and low during illumination. The melatonin rhythm persisted in constant darkness but was suppressed in constant illumination. Under diurnal lighting, cortisol concentrations were elevated in the early portion of the light period. This daily rhythmicity of cortisol secretion was not altered by constant illumination or constant darkness. The differential response of the two hormones to constant light suggests that the daily fluctuation of melatonin secretion was not responsible for the daily rhythmicity of cortisol secretion in the rhesus monkey.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 26 March 2008

Volume: 32

Issue: 4

Pages: 193-196

Affiliations

Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C.; Laboratory of Developmental Neurobiology, National Institute Child Health and Human Development, Bethesda, Md., and Department of Internal Medicine, Southwestern Medical School, Dallas, Tex., USA

Article

Publisher ID: 123157 Other ID: Neuroendocrinology 1981;32:193–196

DOI: 10.1159/000123157

PubMed ID: 7194425

SO-VID: dfc45dbf-0f72-4aaf-bb02-d3b3d13885e3

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 08 July 1980

Date accepted : 25 September 1980

Page count

Pages: 4

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