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Psychosocial predictors of depression and anxiety in patients with epilepsy: A systematic review
Author(s):
Milena Gandy
,
Louise Sharpe
,
Kathryn Nicholson Perry
Publication date
Created:
November 2012
Publication date
(Print):
November 2012
Journal:
Journal of Affective Disorders
Publisher:
Elsevier BV
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
People with epilepsy (PWE) have a high chance of experiencing depression and anxiety disorders over their lifetime. However, those most at risk are unknown. Psychosocial variables have been suggested as potentially important risk factors. A systematic review was conducted in order to critically assess available evidence regarding the psychosocial predictors of depression and anxiety in adults with epilepsy. Electronic databases searched were MEDLINE, PsycINFO and Web of Science. Studies were included if they assessed depressive or anxiety symptoms using a validated questionnaire, and controlled for the role of potentially important epilepsy factors. Eleven studies were identified and assessed for research standards using the Quality Index Scale (QIS). Ten of the eleven studies found at least one significant predictor of depression and all six studies that assessed anxiety found one or more significant predictors. Overall QIS score was only 7.5 out of 15, indicating significant design limitations of many included studies. There was also large variability between studies in measures used to assess psychosocial variables. Studies did not support the importance of attributional theory and stigma in the development of depression in epilepsy. There was inconsistent support for the role of illness representations but likely support for the role of stress and self-efficacy. Consistent support was found for the role of coping strategies and perceived social support. Given that psychosocial factors are potentially modifiable, a better understanding of their role in the development of depression in people with epilepsy is urgently needed to guide effective treatments. Copyright © 2011 Elsevier B.V. All rights reserved.
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Measurement of Glucocorticoid Receptor Signaling in Major Depression
Author and article information
Journal
Title:
Journal of Affective Disorders
Abbreviated Title:
Journal of Affective Disorders
Publisher:
Elsevier BV
ISSN (Print):
01650327
Publication date Created:
November 2012
Publication date (Print):
November 2012
Volume
: 140
Issue
: 3
Pages
: 222-232
Article
DOI:
10.1016/j.jad.2011.11.039
PubMed ID:
22197509
SO-VID:
dfc69f5b-bc79-4b1c-8251-02854b6f4a2e
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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