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Clinicopathologic analysis of coxsackievirus a6 new variant induced widespread mucocutaneous bullous reactions mimicking severe cutaneous adverse reactions.
Wen-Hung Chung
1 ,
Shin-Ru Shih ,
Ching-Fen Chang ,
Tzou-Yien Lin ,
Yhu-Chering Huang ,
Shih-Chen Chang ,
Ming-Tsan Liu ,
Yu-Shien Ko ,
Ming-Chung Deng ,
Yea-Ling Liau ,
Lung-Huang Lin ,
Tou-Hwei Chen ,
Chih-Hsun Yang ,
Hsin-Chun Ho ,
Jheng-Wei Lin ,
Chun-Wei Lu ,
Chin-Fang Lu ,
Shuen-Iu Hung
Dec 15 2013
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Abstract
The cutaneous manifestations of human enterovirus (HEV) infection are usually limited, such as hand-foot-mouth disease. By comparison, Stevens-Johnson syndrome (SJS) is a life-threatening severe cutaneous adverse reaction (SCAR), mainly caused by drugs. During the HEV outbreaks in 2010-2012 in Taiwan, we identified 21 patients who developed widespread blistering mucocutaneous reactions without any suspected drug causality.