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      The Effect of a Diphosphonate on Uremic Hyperparathyroidism

      Nephron

      S. Karger AG

      Bone, Diphosphonate, Uremia

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          Abstract

          Chronic renal failure in the rat was shown to be associated with parathyroid enlargement, a decreased ash content of the femoral shaft and elevated trabecular bone resorption. The diphosphonate, ethane-1 -hydroxy-1,1-diphosphonate was ineffectual in the dose used in altering the manifestation of hyperparathyroidism even though more of the compound was retained in the skeleton of the uremic animals than in the controls.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2495-7
          978-3-318-02023-6
          1660-8151
          2235-3186
          1973
          1973
          27 November 2008
          : 10
          : 2-3
          : 188-194
          Affiliations
          Department of Medicine, Division of Nephrology, The Montreal General Hospital, Montreal, Que.
          Article
          180186 Nephron 1973;10:188–194
          10.1159/000180186
          4710979
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          Diphosphonate, Bone, Uremia

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