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      L-asparaginase induces in AML U937 cells apoptosis via an AIF-mediated mechanism.

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          Abstract

          Acute Myeloid Leukemia (AML), a cancer of the myeloid line of blood cells, progresses rapidly and is typically fatal within weeks or months if left untreated. Asparaginases are a class of enzymatic anti-leukemia agents that induce apoptosis in leukemia cell lines; however, the role of L-asparaginase in the induction of apoptosis in AML cells has not been investigated. In this study, we investigated the apoptosis-inducing effect of L-asparaginase and its underlying mechanism in AML U937 cells. The results showed that L-asparaginase significantly inhibited the proliferation of U937 cells by inducing apoptosis. Furthermore, the low baseline expression level of asparaginase synthase (ASNS) demonstrated the sensitivity of U937 cells and AML M5, a rare subtype of AML, to L-asparaginase. Apoptosis induced by L-asparaginase is mediated by apoptosis-inducing factor (AIF). Our findings show the potential of L-asparaginase as an effective approach in treating AML via the induction of apoptosis mediated by AIF.

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          Author and article information

          Journal
          Front Biosci (Landmark Ed)
          Frontiers in bioscience (Landmark edition)
          1093-4715
          1093-4715
          Jan 01 2014
          : 19
          Affiliations
          [1 ] Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College,Guangzhou, 510623, China.
          [2 ] Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
          [3 ] Department of , Children's Hospital of Shanghai, Shanghai Jiao Tong University, 200040, Shanghai, China.
          Article
          4222
          24389199
          dfd4e961-4c44-4379-b8f3-f03ed8d6f8a2
          History

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