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Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model

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      Abstract

      In order to investigate and evaluate the effects of red deer antlers on hair growth in the full-thickness wound healing model, Sprague-Dawley rats were given incision wounds through the full thickness of their dorsal skin and deer antler was applied for 40 days. At specified intervals thereafter (4, 8, 16, 32 and 40 days), the animals were sacrificed and the wound site skins were excised, processed, and sectioned. At post-injury days 16, 32 and 40, longer and more active new hair appeared around the healing wound of antler-treated skin. Histological studies showed that the antler extract markedly increases the depth, size, and number of hair follicles. Expression of IGF-I (insulin-like growth factor) mRNA was detected by RT-PCR and real time RT-PCR. The result showed that the expression of IGF-I (days 16, 32, and 40) was obviously up-regulated in antler-treated skins compared to control skins. Similar results were seen in the ELISA analysis to quantify the IGF-I expression. These results support the notion that wound healing can cause hair growth by enhancing the expression of IGF-I. Deer antler extract appears to have the potential to promote hair growth and could be used in hair growth products.

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      Most cited references 30

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            Author and article information

            Affiliations
            [1 ]Colloge of life science, Huzhou University, Huzhou, Zhejiang 31300, China.
            Author notes
            [* ]Corresponding Author: Changkeun Sung. Tel: +82-42-821-6722, Fax: +82-42-822-2287, E-mail: kchsung@ 123456cnu.ac.kr

            Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Korea

            [a]

            ZhiHong Yang and Author LiJuan Gu contributed to this work equally.

            Journal
            Asian-Australas J Anim Sci
            Asian-australas. J. Anim. Sci
            Asian-Australasian Journal of Animal Sciences
            Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST)
            1011-2367
            1976-5517
            May 2012
            01 May 2012
            : 25
            : 5
            : 708-716
            4093112
            10.5713/ajas.2011.11246
            ajas-25-5-708-16
            Copyright © 2012 by Asian-Australasian Journal of Animal Sciences

            This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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