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      Dyslipidemia in Iranian overweight and obese children

      Therapeutics and Clinical Risk Management

      Dove Medical Press

      dyslipidemia, lipid profile, obesity, overweight, children, adolescents

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          Abstract

          Objective:

          To evaluate the frequency and patterns of dyslipidemia in overweight and obese children and to determine the extent of blood lipid abnormality in overweight and obese children.

          Methods:

          A prospective matched case control study on 230 overweight and obese children and adolescents (body mass index [BMI] > 85th percentile) aged 4 to 18 years undertaken at the outpatient endocrine clinic of the Childrens’ Hospital at Tabriz University between 2006–2008. This study was conducted to compare the frequency of abnormal plasma lipid levels in overweight and obese children compared with 50 nonobese children (BMI = 50th–85th percentile).

          Results:

          The total frequency of dyslipidemia was 69.58%. The prevalence of dyslipidemia increased with severity of obesity and reached 76.9% in the severely obese ( P < 0.005). High triglycerides was the most common dyslipidemia in combination (26.08%) and in isolation (18.6%). There was a significant difference in mean of triglycerides between the severely obese and other groups ( P < 0.004).

          Conclusion:

          In the present study, dyslipidemia is more common in severely obese children and the most common component of dyslipidemia is a high triglyceride level.

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          Most cited references 3

          • Record: found
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          Lipid abnormalities in the metabolic syndrome.

           Eliot Brinton (2003)
          The metabolic syndrome is the constellation of adverse metabolic and clinical effects of insulin resistance. Its high and increasing prevalence and its profound impact on the major diseases of the western world require that clinicians consider its diagnosis and management on a routine basis. Recently published guidelines on its definition now make convenient and reliable diagnosis possible. Also, there is new and better understanding of the complex dyslipidemias and other risk factors strongly associated with the metabolic syndrome, which greatly increase the risk of clinical atherosclerotic events. Comprehensive clinical evaluation of these dyslipidemias and associated atherosclerosis risk factors can lead to their aggressive treatment, customized according to the circumstances of each patient. These steps are now more feasible and more clearly desirable than ever before. Statins alone greatly reduce atherosclerosis risk, but combination lipid therapy is often required for optimal dyslipidemia management and atheroprevention.
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            The PDAY Study: natural history, risk factors, and pathobiology. Pathobiological Determinants of Atherosclerosis in Youth.

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              • Record: found
              • Abstract: found
              • Article: not found

              [Plasma lipid profile and lipid peroxidation in overweight or obese children and adolescents].

              To study the plasma lipid profile and lipid peroxidation in overweight or obese children and adolescents receiving care at the pediatric endocrinology clinic in HOSPED/UFRN, a university hospital.
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                Author and article information

                Journal
                Ther Clin Risk Manag
                Therapeutics and Clinical Risk Management
                Therapeutics and Clinical Risk Management
                Dove Medical Press
                1176-6336
                1178-203X
                2009
                2009
                24 September 2009
                : 5
                : 739-743
                Affiliations
                Department of Pediatrics, Tabriz University (Medical Sciences), Tabriz, Iran
                Author notes
                Correspondence: R Ghergerehchi, Department of Pediatrics, Tabriz University (Medical Sciences), Tabriz, Iran, Email ghergherehchir@ 123456yahoo.com
                Article
                tcrm-5-739
                2754088
                19816572
                © 2009 Ghergerehchi, publisher and licensee Dove Medical Press Ltd.

                This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

                Categories
                Original Research

                Medicine

                overweight, lipid profile, obesity, adolescents, dyslipidemia, children

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