The Link Between Adipose Tissue Renin-Angiotensin-Aldosterone System Signaling and Obesity-Associated Hypertension.

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Abstract

Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.

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Journal

Journal ID (iso-abbrev): Physiology (Bethesda)

Title: Physiology (Bethesda, Md.)

Publisher: American Physiological Society

ISSN (Electronic): 1548-9221

ISSN (Print): 1548-9221

Publication date (Electronic): May 2017

Volume: 32

Issue: 3

Affiliations

[1 ] Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.

[2 ] Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands cda.stehouwer@mumc.nl.

Article

Publisher Item ID: 32/3/197

DOI: 10.1152/physiol.00037.2016

PubMed ID: 28404736

SO-VID: dfe07030-531c-4d0b-a833-45042ef5680f

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