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      Clinical recovery and health-related quality of life in ischaemic stroke survivors receiving thrombolytic treatment: a 1-year follow-up study.

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          Abstract

          The aims of this study were to examine prospectively the course of neurological and functional recovery and health related quality of life (HRQoL) in ischaemic stroke patients after intravenous thrombolysis, to assess the 1-year outcome and to determine the early predictors. A group of 53 consecutive patients were assessed at admission to the acute stroke unit (T0), before their discharge (T1), and at 3 (T2) and 12 (T3) months after hospital discharge. The National Institutes of Health Stroke Scale (NIHSS), the Barthel Index (BI) and the Stroke Specific Quality of Life Scale (SSQoL) were used to evaluate stroke severity, functional disability and health related quality of life (HRQoL). A good outcome was defined as simultaneous improvement in all three scales. At T0, 83 % of the patients had severe or moderate neurological impairment. Additionally, 77 % demonstrated very severe or severe disability when assessed by the BI. 74 and 79 % of the patients reported an acceptable HRQoL at 3 and 12 months following discharge, respectively. Neurological and functional status improved significantly over time with most changes occurring during hospitalization and the subsequent 3 months. At T3, 75.5 % of the patients had the good outcome which had been independently predicted by the level of stroke related disability at T0. A majority of the stroke survivors treated with thrombolysis achieved a good outcome. The measurement of stroke specific HRQoL, as a tool for gathering information from the patient, should be incorporated in the assessment of post-stroke recovery and outcome.

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          Author and article information

          Journal
          J. Thromb. Thrombolysis
          Journal of thrombosis and thrombolysis
          Springer Nature
          1573-742X
          0929-5305
          Jan 2017
          : 43
          : 1
          Affiliations
          [1 ] Department of Neurological and Psychiatric Nursing, Poznan University of Medical Sciences, Smoluchowski 11 str., 61-170, Poznan, Poland. bgfudala@ump.edu.pl.
          [2 ] Department of Neurological and Psychiatric Nursing, Poznan University of Medical Sciences, Smoluchowski 11 str., 61-170, Poznan, Poland.
          [3 ] Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
          [4 ] Department of Neurology and Cerebrovascular Disorders, L. Bierkowski Hospital, Poznan University of Medical Sciences, Poznan, Poland.
          Article
          10.1007/s11239-016-1419-3
          10.1007/s11239-016-1419-3
          27613176
          e00e6a17-0d18-448c-bc5d-bab383ba2076
          History

          Clinical status,Outcome,Quality of life,Stroke,Thrombolytic therapy

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