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Eukaryotic protein elongation factors
November 1990
November 1990
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Abstract
In eukaryotes, peptide chain elongation is mediated by elongation factors EF-1 and
EF-2. EF-1 is composed of a nucleotide-binding protein EF-1 alpha, and a nucleotide
exchange protein complex, EF-1 beta gamma, while EF-2 catalyses the translocation
of peptidyl-tRNA on the ribosome. Elongation factors are highly conserved among different
species and may be involved in functions other than protein synthesis, such as organization
of the mitotic apparatus, signal transduction, developmental regulation, ageing and
transformation. Yeast contains a third factor, EF-3, whose structure and function
is not yet well understood.