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      Captopril-Induced Proteinuria in Hypertensive Psoriatic Patients

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          We have previously reported on a high prevalence of high renin essential hypertension in psoriasis. Since angiotensin-converting enzyme (ACE) was also reported to be increased in some psoriatics, we found it rational to treat 10 patients with hypertension and diffuse psoriasis with captopril at a dose of 25 mg t.i.d. Five patients had high PRA levels and in 1 of them serum ACE was also increased. Serum creatinine, BUN and urinalysis were normal in all of them. SPB fell from 163 ± 3 to 138 ± 3 and DBP from 107 ± 3 to 86 ± 2 mm Hg after 1 month of captopril treatment. A surprising clinical improvement of the cutaneous lesions occured in 3 patients previously resistant to every local or systemic treatment. Unfortunately, however, 3 patients developed heavy proteinuria ( > 2 g/day) which disappeared after captopril discontinuation. The unexpected incidence of reversible proteinuria induced by low doses of captopril in our patients recommends a careful monitoring of the renal function every time this drug is employed in the treatment of hypertension in a psoriatic.

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          Author and article information

          S. Karger AG
          05 December 2008
          : 44
          : 4
          : 358-360
          aCattedra di Patologia Medica II and bClinica Dermatologica, University of Sassari, Italy
          184020 Nephron 1986;44:358–360
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 3
          Original Paper

          Cardiovascular Medicine, Nephrology

          Proteinuria, Psoriasis, Hypertension, Captopril


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