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      Potential Role for Growth Hormone in Human Lactation Insufficiency

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          In order to evaluate the galactopoietic response to rhGH in mothers of normal babies with idiopathic lactation insufficiency arising in the early postpartum period, we performed a preliminary, randomised, single blind trial of 3 different doses of hGH: either 0.05, 0.1, or 0.2 IU/kg/day to a maximum of 16 IU/day, for 7 days. Total 24-hour milk production was determined in each mother 1 day prior to initiating therapy and on the last day of therapy. Milk production rose by 36.0 ± 12.6% in the group receiving 0.2 IU/kg/day (n = 6) but by only 4.7 ± 9.7%, (p < 0.04) in the combined lower dose group (n = 10). In conclusion, these data suggest that moderate dose hGH therapy in mothers with lactation insufficiency can improve galactopoiesis.

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          Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution


            Author and article information

            Horm Res Paediatr
            Hormone Research in Paediatrics
            S. Karger AG
            September 1998
            08 October 1998
            : 50
            : 3
            : 147-150
            Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand
            23263 Horm Res 1998;50:147–150
            © 1998 S. Karger AG, Basel

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            Figures: 1, Tables: 1, References: 22, Pages: 4
            Original Paper


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